penicilloicadj.
/ˌpɛnᵻsɪˈləʊɪk/, U.S. /ˈˌpɛnəsəˈloʊɪk/ Biochemistry.
penicilloic acid n. any of a group of acids which are dicarboxylic acid derivatives of thiazolidine and are produced when penicillins are hydrolysed (as by a penicillinase) and the carbon–nitrogen bond of the lactam ring is broken.
ΚΠ
1945 Science 21 Dec. 628/2 The dicarboxylic acid obtained by hydrolysis of penicillin at the site of the potential carboxyl is termed penicilloic acid.
1949 R. Mozingo & K. A. Folkers in H. T. Clarke et al. Chem. of Penicillin xviii. 542/1 Many of the penicilloic acids..were made in order to study their reactions with various reagents in the interest of their dehydration to the penicillins.
1959 Observer 11 Jan. 14/7 It [sc. penicillinase] acts by rapidly breaking down penicillin to penicilloic acid, which has no antibiotic activity.
1984 M. J. Taussig Processes in Pathol. & Microbiol. (ed. 2) ii. 160 In the drug-induced haemolytic anaemias, exemplified by that associated with penicillin, the drug or one of the reactive products of its metabolism or degradation (e.g. penicilloic acid) functions as a hapten and becomes attached to the red cell membrane.
2003 Biochem. Engin. Jrnl. 14 19 Beta-lactamases are enzymes that deactivate penicillins..by hydrolyzing their beta-lactam rings, producing penicilloic acid derivatives.
This entry has been updated (OED Third Edition, September 2005; most recently modified version published online March 2022).
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adj.1945