penicillaminen.
/ˌpɛnᵻˈsɪləmiːn/, U.S. /ˌpɛnəˈsɪləˌmin/ Chemistry and Pharmacology.
A crystalline, sulphur-containing amino acid produced by the hydrolysis of penicillins, used pharmacologically as a chelating agent to remove heavy metals such as copper from the body, and as an anti-inflammatory agent, esp. for rheumatoid arthritis; 2-amino-3-methyl-3-mercaptobutanoic acid, (CH3)2C(SH)CH(NH2)COOH.
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the world > health and disease > healing > medicines or physic > other miscellaneous medicines > [noun]
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penicillamine1943
1943 E. P. Abraham et al. in Nature 23 Jan. 107/1 The properties of this substance, which we propose to term penicillamine, show that it represents a novel type of naturally occurring base.
1967 Brain 90 154 Copper transport and excretion in normal individuals can be modified by the administration of the chelating agent penicillamine.
1977 Davidson's Princ. & Pract. Med. (ed. 12) 733 This disorder [sc. Wilson's disease]..can now be arrested by giving copper-binding drugs (chelating agents)... The most valuable of these is penicillamine.
2001 Guardian 10 Sept. i. 4/6 Other mistakes were giving penicillamine, for arthritis, rather than the antibiotic penicillin; and Lamictal, to control epilepsy, rather than Lamisil, an anti-fungal treatment.
This entry has been updated (OED Third Edition, September 2005; most recently modified version published online March 2022).
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n.1943