paracrineadj.
/ˈparəkriːn/, /ˈparəkrʌɪn/, U.S. /ˈpɛrəkr(ə)n/ Physiology.
Designating a hormone whose effects are confined to tissues in the vicinity of the gland secreting it; of or relating to such a hormone.
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adipokinetic1947
paracrine1952
mineralocorticoid1954
1952 tr. F. Feyrter in Acta Neurovegetativa 4 422 In addition to the central compact endocrine glands there are also peripheral endocrine (paracrine) glands in the exterior and interior surfaces of the body.
1972 F. Feyrter in Endocrinol. 1971 137 The hypothesis of the peripheral entodermal endocrine (paracrine) glands was confirmed (1) by the evidence of a pressor agent in the enteral carcinoid.., (2) by the discovery of the islet cells of the pancreatic duct with A and B cells, their endocrine function having already been established.
1976 Nature 8 July 92/3 The actions of this hormone are paracrine, directed that is to neighbouring cells and tissue, rather than truly endocrine.
1991 Lancet 9 Mar. 614/1 Stimulation of paracrine cell mitogenesis by hormones may be an important factor in human carcinogenesis.
2001 Alternative Therapies in Health & Med. Mar. 71/1 Cytokins can best be defined as small proteins..that usually act in an autocrine (ie, on the cell that produced them) or paracrine manner (ie, on cells close by).
This entry has been updated (OED Third Edition, June 2005; most recently modified version published online March 2022).
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adj.1952