pamaquinn.

Brit.

/ˈpaməkwɪn/, U.S.

/ˈpæməˌkwɪn/

Forms: 1900s– pamaquin, 1900s– pamaquine.

Origin: Formed within English, by compounding. Etymons: pentane n., amino- comb. form, methoxy- comb. form, English -a- , quinoline n., quinine n.

Etymology: < p- (in pentane n.) + a- (in amino- comb. form) + m- (in methoxy- comb. form) + -a-, connective (compare -i- connective) + quin- (in quinoline n. or quinine n.).Components of the molecule include 6-methoxyquinoline and 1,4-pentanediamine groups.

Pharmacology.

A toxic, orange-yellow, quinoline derivative, C₁₉H₂₉N₃O.C₂₃H₁₆O₆, formerly used as an antimalarial drug. Cf. Plasmochin n. and Plasmoquine n.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for malaria

Plasmochin1926

Plasmoquine1926

atebrin1932

quinacrine1934

pamaquin1941

Paludrine1944

chloroquine1946

Resochin1946

proguanil1948

primaquine1949

hydroxychloroquine1951

pyrimethamine1952

mefloquine1974

qinghaosu1979

1941 Brit. Pharmacopœia 1932 Add. iv. 24 Pamaquin is the 6-methoxy-8-[ω-diethylamino-α-methylbutyl]-aminoquinoline salt of 2:2′-dihydroxy-1:1′ -dinaphthylmethane-3:3′-dicarboxylic acid.

1951 A. Grollman Pharmacol. & Therapeutics xxxiii. 483 Because of its toxicity and the availability of safer and better drugs, pamaquine is no longer of therapeutic importance.

1961 New Scientist 4 May 261/1 The anti-malarial drugs pamaquin and primaquine produce anaemia in certain susceptible persons.

1974 B. G. Maegraith in A. W. Woodruff Med. in Tropics ii. 65/1 The 8-aminoquinoline most widely given [for vivax malaria] is primaquine; pamaquine or quinocide are alternatives.

1990 M. Weatherall In Search of Cure (BNC) 193 Primaquine, chemically in the same family as the pre-war German drug pamaquin, emerged as the most notable success of the great US wartime project.

This entry has been updated (OED Third Edition, March 2005; most recently modified version published online March 2022).

单词	pamaquin
释义	pamaquinn. Brit. /ˈpaməkwɪn/, U.S. /ˈpæməˌkwɪn/ Forms: 1900s– pamaquin, 1900s– pamaquine. Origin: Formed within English, by compounding. Etymons: pentane n., amino- comb. form, methoxy- comb. form, English -a- , quinoline n., quinine n. Etymology: < p- (in pentane n.) + a- (in amino- comb. form) + m- (in methoxy- comb. form) + -a-, connective (compare -i- connective) + quin- (in quinoline n. or quinine n.).Components of the molecule include 6-methoxyquinoline and 1,4-pentanediamine groups. Pharmacology. A toxic, orange-yellow, quinoline derivative, C₁₉H₂₉N₃O.C₂₃H₁₆O₆, formerly used as an antimalarial drug. Cf. Plasmochin n. and Plasmoquine n. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for malaria Plasmochin1926 Plasmoquine1926 atebrin1932 quinacrine1934 pamaquin1941 Paludrine1944 chloroquine1946 Resochin1946 proguanil1948 primaquine1949 hydroxychloroquine1951 pyrimethamine1952 mefloquine1974 qinghaosu1979 1941 Brit. Pharmacopœia 1932 Add. iv. 24 Pamaquin is the 6-methoxy-8-[ω-diethylamino-α-methylbutyl]-aminoquinoline salt of 2:2′-dihydroxy-1:1′ -dinaphthylmethane-3:3′-dicarboxylic acid. 1951 A. Grollman Pharmacol. & Therapeutics xxxiii. 483 Because of its toxicity and the availability of safer and better drugs, pamaquine is no longer of therapeutic importance. 1961 New Scientist 4 May 261/1 The anti-malarial drugs pamaquin and primaquine produce anaemia in certain susceptible persons. 1974 B. G. Maegraith in A. W. Woodruff Med. in Tropics ii. 65/1 The 8-aminoquinoline most widely given [for vivax malaria] is primaquine; pamaquine or quinocide are alternatives. 1990 M. Weatherall In Search of Cure (BNC) 193 Primaquine, chemically in the same family as the pre-war German drug pamaquin, emerged as the most notable success of the great US wartime project. This entry has been updated (OED Third Edition, March 2005; most recently modified version published online March 2022). < n.1941
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