pachydermian.
/ˌpakɪˈdəːmɪə/, U.S. /ˌpækəˈdərmiə/ Medicine.
Abnormal thickening of the skin. Also: abnormal thickening of a mucous membrane, esp. of the larynx.
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1874 W. Tay tr. F. Hebra & M. Kaposi On Dis. Skin III. xxxix. 130 (note) Though the name, Pachydermia, proposed by Fuchs, appears less misleading..than that of Elephantiasis Arabum, yet we have felt compelled to prefer the latter title.
1887 Retrospect Med. 96 44 The description of pachydermia he [sc. Virchow] thus sums up: In a certain restricted area of the larynx, under irritation, two kinds of proliferation may occur, resembling chronic inflammation.
1949 H. W. C. Vines Green's Man. Pathol. (ed. 17) xxiv. 628 In the chronic condition [of laryngeal inflammation] the mucous membrane becomes thickened (pachydermia), and granular projecting nodules of hyperplastic mucous membrane appear.
1966 Geogr. Rev. 56 399 A heavily infested skin will show signs of atrophy, diminished elasticity, and the thickening known as pachydermia, or ‘elephant skin’.
1992 Clin. & Exper. Rheumatol. 10 (Suppl. 7) 45 Pachydermoperiostosis (PDP) is characterized by finger clubbing, periostosis and peculiar skin involvement (pachydermia, seborrhea and folliculitis).
2002 Laryngoscope 112 1019 Interarytenoid pachydermia, likelihood of LPRD [= laryngopharyngeal reflux disease] involvement, and severity of LPRD findings were assessed.
Derivatives
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the world > health and disease > ill health > a disease > disorders of visible parts > skin disorders > [adjective] > hardening or thickening
parakeratotic1896
pachydermial1897
sclerodermatous1899
sclerodermic1899
1897 T. C. Allbutt et al. Syst. Med. IV. 832 Chronic inflammation of the mucous membrane of the larynx..may exist with the pachydermial affection.
This entry has been updated (OED Third Edition, March 2005; most recently modified version published online March 2022).
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n.1874