osteoidadj.n.

1840 C. West tr. J. Müller Nature of Cancer I. ii. i. 136 The osteoid tumor [Ger. Osteoid] of the bones..is a growth composed entirely of osseous substance.

1859 Proc. Royal Soc. 1857–9 9 662 It seems to follow that the peculiar distribution of real osseous tissue and of the ‘osteoid’ structure, as the osseous tissue without corpuscles may be called, has a deeper signification.

1859 S. Wilks Lect. Pathol. Anat. i. 31 There is encephaloid and scirrhous cancer of bone,..if the latter is wholly ossified, we have osteoid cancer.

1870 G. Rolleston Forms Animal Life 46 In their bony or osteoid tissue fish resemble the Amphibia.

1899 T. C. Allbutt et al. Syst. Med. VI. 9 Normally in molluscs, osteoid fish, and reptiles, only two cusps form.

1916 E. H. Kettle Pathol. Tumours ii. 96 A tumour may form osteoid tissue consisting of trabeculæ, almost typical in every respect except that there is no deposition of calcium salts in the matrix.

1950 A. W. Ham Histol. xvi. 190/2 Under normal conditions..newly formed bone exists in an uncalcified or osteoid state for only a transitory period.

1969 W. A. Beresford Lect. Notes Histol. vii. 49 The osteoid seam is a very poorly mineralized zone of matrix, 1–3 μ wide, seen with light microscopy between the true bone and the active osteoblasts.

2000 Jrnl. Vet. Med. Sci. 62 69 The mean trabecular thickness and the fraction of labeled osteoid surface decreased significantly 3 months after orchidectomy.

1845 Brit. & Foreign Med. Rev. 19 535 Osteoids appearing after removal of carcinoma of the breast, or carcinoma following the removal of osteoid tumours.

1847–9 Todd's Cycl. Anat. & Physiol. IV. i. 135/2 Osteoid.—Under the names of osteoid or ossifying fungous tumour, Müller describes a growth..composed of a greyish white, vascular, nodulated substance, of the consistence of fibro-cartilage.

1854 W. E. Swaine tr. C. von Rokitansky Man. Pathol. Anat. I. ix. 181 This series [of new-growths]..separates into the osteoid, and into the bony concretion.

1854 W. E. Swaine tr. C. von Rokitansky Man. Pathol. Anat. I. ix. 185 Müller's osteoid is a bone-formation which enters redundantly into the parenchyma of cancer.

1920 A. F. Hess Scurvy v. 134 An irregular line of ossification and ‘a framework’ marrow, which, however, showed regions of osteoid.

1934 Vet. Jrnl. 90 157 They were not considered to be genuinely rachitic, because the pathognomic osteoid formation was absent, or the amount of osteoid was not considered sufficient.

1943 Bull. Johns Hopkins Hosp. 72 236 Osteoid in the normal adult individual is usually absent or very scanty.

1963 K. V. F. Jubb & P. C. Kennedy Pathol. Domest. Animals I. i. 9/2 Osteoid consists of fibrillar protein (collagen) in a non-fibrillar medium which is probably largely of mucopolysaccharides.

1972 H. L. Jaffe Metabolic Dis. Bones xv. 387 It is the presence of abundant osteoid that characterizes the histologic picture of both rickets and osteomalacia.

1989 B. Alberts et al. Molecular Biol. Cell (ed. 2) xvii. 991 (caption) How osteoblasts lining the surface of bone secrete the organic matrix of bone (osteoid) and are converted into osteocytes as they become embedded in this matrix.

1935 H. L. Jaffe in Arch. Surg. 31 724 One feels forced to conclude that one is dealing here with a benign bone neoplasm the distinctiveness of which has not hitherto been recognized and which I am designating ‘osteoid-osteoma’.

1966 G. P. Wright & W. S. Symmers Systemic Pathol. I. xxxvii. 1400 An osteoid osteoma takes the form of a rounded mass of gritty, reddish-grey tissue... Histologically.., the lesion consists of vascular osteoblastic tissue, containing much osteoid matrix and some calcified bone.

1989 J. A. B. Collier & J. M. Longmore Oxf. Handbk. Clin. Specialties (ed. 2) ix. 620 When scoliosis gives pain in a child or adolescent (especially at night), an osteoid osteoma, osteoblastoma, severe spondylolisthesis or spinal tumours may be the cause.