osteoclasticadj.

Brit.

/ˌɒstɪəʊˈklastɪk/, U.S.

/ˈˌɑstioʊˈklæstɪk/

Origin: Formed within English, by compounding. Etymons: osteo- comb. form, -clastic comb. form.

Etymology: < osteo- comb. form + -clastic comb. form, after osteoclast n. or osteoclasis n.

Physiology and Pathology.

Of or relating to osteoclasts or osteoclasis.

ΚΠ

1900 W. A. N. Dorland Amer. Illustr. Med. Dict. 466/1 Osteoclastic, pertaining or of the nature of an osteoclast; destructive to bone.

1934 Amer. Jrnl. Dis. Children 47 968 There was some lacunar resorption through osteoclastic activity.

1949 H. W. C. Vines Green's Man. Pathol. (ed. 17) xv. 386 Sarcoma of bone is generally divided into two types, osteogenic sarcoma and osteoclastic sarcoma (osteoclastoma).

1981 R. N. Hardy Endocrine Physiol. viii. 110 Calcitonin appears to work principally on the cells within bone and reduces both osteocytic and osteoclastic activity.

1996 Jrnl. Cell. Physiol. 167 365/2 The inability of minocycline to completely inhibit osteoid degradation, and consequently osteoclastic resorption, may be related to the doses used.

2004 Amer. Jrnl. Therapeutics 11 60 They [sc. biphosphonates] are effective in diseases in which there is clear upregulation of osteoclastic or osteolytic activity such as breast cancer and multiple myeloma.

This entry has been updated (OED Third Edition, September 2004; most recently modified version published online March 2022).

单词	osteoclastic
释义	osteoclasticadj. Brit. /ˌɒstɪəʊˈklastɪk/, U.S. /ˈˌɑstioʊˈklæstɪk/ Origin: Formed within English, by compounding. Etymons: osteo- comb. form, -clastic comb. form. Etymology: < osteo- comb. form + -clastic comb. form, after osteoclast n. or osteoclasis n. Physiology and Pathology. Of or relating to osteoclasts or osteoclasis. ΚΠ 1900 W. A. N. Dorland Amer. Illustr. Med. Dict. 466/1 Osteoclastic, pertaining or of the nature of an osteoclast; destructive to bone. 1934 Amer. Jrnl. Dis. Children 47 968 There was some lacunar resorption through osteoclastic activity. 1949 H. W. C. Vines Green's Man. Pathol. (ed. 17) xv. 386 Sarcoma of bone is generally divided into two types, osteogenic sarcoma and osteoclastic sarcoma (osteoclastoma). 1981 R. N. Hardy Endocrine Physiol. viii. 110 Calcitonin appears to work principally on the cells within bone and reduces both osteocytic and osteoclastic activity. 1996 Jrnl. Cell. Physiol. 167 365/2 The inability of minocycline to completely inhibit osteoid degradation, and consequently osteoclastic resorption, may be related to the doses used. 2004 Amer. Jrnl. Therapeutics 11 60 They [sc. biphosphonates] are effective in diseases in which there is clear upregulation of osteoclastic or osteolytic activity such as breast cancer and multiple myeloma. This entry has been updated (OED Third Edition, September 2004; most recently modified version published online March 2022). < adj.1900
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