osteoclasisn.

Brit.

/ˌɒstɪəʊˈkleɪsɪs/, U.S.

/ˈˌɑstioʊˈkleɪsᵻs/

Origin: A borrowing from Greek, combined with an English element. Etymons: osteo- comb. form, Greek κλάσις.

Etymology: < osteo- comb. form + ancient Greek κλάσις fracture (see -clase comb. form). Compare earlier diaclasis n. With sense 2 compare earlier osteoclast n. 1.

1. Surgery. Intentional fracturing of a bone, esp. to correct a deformity.

ΚΠ

1848 R. Dunglison Med. Lexicon (ed. 7) 612/1 Osteoclasis, fracture.

1884 Therapeutic Gaz. 15 Dec. 568/2 One hundred and forty-eight pages are devoted to osteotomy, and twenty-six pages to osteoclasis.

1890 E. H. Bradford & R. W. Lovett Treat. Orthopedic Surg. xx. 684 Osteoclasis is a simple procedure... The fracture of the bones is evidenced by a loud snap.

1904 R. Whitman Orthopedic Surg. (ed. 2) xvi. 573 Osteoclasis, by means of the Grattan osteoclast, is an effective operation. With this instrument the bone may be broken above the condyles at the desired point.

1949 T. L. Waring in J. S. Speed Campbell's Operative Orthopedics (ed. 2) II. 1601 Krida advocates correction of anteversion by manual osteoclasis.

1971 Clin. Orthopaedics No. 77. 128 (title) Controlled closed rotational osteoclasis of the femur.

2002 Jrnl. Bone & Joint Surg. 84A 1579 Both an osteotomy and osteoclasis were used to create a model of an intra-articular fracture of the distal part of the radius.

2. Pathology and Physiology. Destruction of bone; spec. resorption of bone by osteoclasts.

ΚΠ

1890 Cent. Dict. Osteoclasis, the dissolution or resorption of osseous tissue; the destruction of bone.

1928 S. Moore & J. A. Key tr. R. Leriche & A. Policard Normal & Pathol. Physiol. Bone iv. 78 In osteoclasis the bone cells disappear.

1949 Biol. Rev. 24 462 Generalized osteoclasis can be produced by a variety of methods such as the injection of parathyroid extracts.

1981 R. N. Hardy Endocrine Physiol. ii. 13 The dissolution of bone depends in part on the stimulation of lysosymal enzymes within osteocytes (osteolysis) and osteoclasts (osteoclasis), thereby breaking down the organic matrix of the bone.

2003 Jrnl. Pathol. 201 504 An important regulator of osteoclast activity is the process of apoptosis, and any aberration in this process could lead to increased osteoclasis.

This entry has been updated (OED Third Edition, September 2004; most recently modified version published online March 2022).

单词	osteoclasis
释义	osteoclasisn. Brit. /ˌɒstɪəʊˈkleɪsɪs/, U.S. /ˈˌɑstioʊˈkleɪsᵻs/ Origin: A borrowing from Greek, combined with an English element. Etymons: osteo- comb. form, Greek κλάσις. Etymology: < osteo- comb. form + ancient Greek κλάσις fracture (see -clase comb. form). Compare earlier diaclasis n. With sense 2 compare earlier osteoclast n. 1. 1. Surgery. Intentional fracturing of a bone, esp. to correct a deformity. ΚΠ 1848 R. Dunglison Med. Lexicon (ed. 7) 612/1 Osteoclasis, fracture. 1884 Therapeutic Gaz. 15 Dec. 568/2 One hundred and forty-eight pages are devoted to osteotomy, and twenty-six pages to osteoclasis. 1890 E. H. Bradford & R. W. Lovett Treat. Orthopedic Surg. xx. 684 Osteoclasis is a simple procedure... The fracture of the bones is evidenced by a loud snap. 1904 R. Whitman Orthopedic Surg. (ed. 2) xvi. 573 Osteoclasis, by means of the Grattan osteoclast, is an effective operation. With this instrument the bone may be broken above the condyles at the desired point. 1949 T. L. Waring in J. S. Speed Campbell's Operative Orthopedics (ed. 2) II. 1601 Krida advocates correction of anteversion by manual osteoclasis. 1971 Clin. Orthopaedics No. 77. 128 (title) Controlled closed rotational osteoclasis of the femur. 2002 Jrnl. Bone & Joint Surg. 84A 1579 Both an osteotomy and osteoclasis were used to create a model of an intra-articular fracture of the distal part of the radius. 2. Pathology and Physiology. Destruction of bone; spec. resorption of bone by osteoclasts. ΚΠ 1890 Cent. Dict. Osteoclasis, the dissolution or resorption of osseous tissue; the destruction of bone. 1928 S. Moore & J. A. Key tr. R. Leriche & A. Policard Normal & Pathol. Physiol. Bone iv. 78 In osteoclasis the bone cells disappear. 1949 Biol. Rev. 24 462 Generalized osteoclasis can be produced by a variety of methods such as the injection of parathyroid extracts. 1981 R. N. Hardy Endocrine Physiol. ii. 13 The dissolution of bone depends in part on the stimulation of lysosymal enzymes within osteocytes (osteolysis) and osteoclasts (osteoclasis), thereby breaking down the organic matrix of the bone. 2003 Jrnl. Pathol. 201 504 An important regulator of osteoclast activity is the process of apoptosis, and any aberration in this process could lead to increased osteoclasis. This entry has been updated (OED Third Edition, September 2004; most recently modified version published online March 2022). < n.1848
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