orotidinen.

Brit.

/ɒˈrɒtᵻdiːn/,

/əˈrɒtᵻdiːn/, U.S.

/ɔˈrɑdəˌdin/

Origin: Formed within English, by derivation. Etymons: orotic adj., -idine suffix.

Etymology: < orot- (in orotic adj.) + -idine suffix.

Biochemistry.

A ribonucleoside containing orotic acid, which is an intermediate in pyrimidine nucleotide synthesis and occurs chiefly as its 5′-monophosphate.

ΚΠ

1951 A. M. Michelson et al. in Proc. National Acad. Sci. U.S.A. 37 396 (heading) A new ribose nucleoside from Neurospora: ‘orotidine’.

1963 A. M. Michelson Chem. Nucleosides & Nucleotides ii. 44 Periodate oxidation and enzymatic synthesis..and conversion into uridine show that orotidine is 3-β- d-ribofuranosylorotic acid.

1977 Cancer Res. 37 4386/2 Accumulation of orotic acid and orotidine has been observed after 6-aza-UR [= 6-azauridine] treatment in bacterial culture media..and human urine.

2002 Jrnl. Molecular Biol. 318 1019 Orotidine 5′-monophosphate decarboxylase (ODCase) catalyses the decarboxylation of orotidine 5′-monophosphate to uridine 5′-monophosphate.

This entry has been updated (OED Third Edition, September 2004; most recently modified version published online March 2022).

单词	orotidine
释义	orotidinen. Brit. /ɒˈrɒtᵻdiːn/, /əˈrɒtᵻdiːn/, U.S. /ɔˈrɑdəˌdin/ Origin: Formed within English, by derivation. Etymons: orotic adj., -idine suffix. Etymology: < orot- (in orotic adj.) + -idine suffix. Biochemistry. A ribonucleoside containing orotic acid, which is an intermediate in pyrimidine nucleotide synthesis and occurs chiefly as its 5′-monophosphate. ΚΠ 1951 A. M. Michelson et al. in Proc. National Acad. Sci. U.S.A. 37 396 (heading) A new ribose nucleoside from Neurospora: ‘orotidine’. 1963 A. M. Michelson Chem. Nucleosides & Nucleotides ii. 44 Periodate oxidation and enzymatic synthesis..and conversion into uridine show that orotidine is 3-β- d-ribofuranosylorotic acid. 1977 Cancer Res. 37 4386/2 Accumulation of orotic acid and orotidine has been observed after 6-aza-UR [= 6-azauridine] treatment in bacterial culture media..and human urine. 2002 Jrnl. Molecular Biol. 318 1019 Orotidine 5′-monophosphate decarboxylase (ODCase) catalyses the decarboxylation of orotidine 5′-monophosphate to uridine 5′-monophosphate. This entry has been updated (OED Third Edition, September 2004; most recently modified version published online March 2022). < n.1951
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