ochronosisn.

Brit.

/ˌəʊkrə(ʊ)ˈnəʊsɪs/, U.S.

/ˌoʊkrəˈnoʊsəs/

Origin: A borrowing from German. Etymon: German Ochronosis.

Etymology: < German Ochronosis (R. Virchow 1866, in Arch. f. path. Anat. u. Physiol. 37 218; now usually Ochronose ) < ancient Greek ὠχρός pale yellow (see ochre n.) + νόσος disease (see noso- comb. form) + -osis -osis suffix.

Medicine.

Abnormal brown pigmentation of tissue (esp. cartilage and ligaments), spec. that resulting from the accumulation of a melanin-like pigment derived from homogentisic acid in the metabolic disorder alkaptonuria.

ΘΚΠ

the world > health and disease > ill health > a disease > diseases of tissue > [noun] > abnormal pigmentation

melanosis1821

ochronosis1867

polychromia1897

1867 Half-yearly Abstr. Med. Sci. 65 28 Virchow proposes to call this affection ochronosis.

1876 J. Van Duyn & E. C. Seguin tr. E. L. Wagner Man. Gen. Pathol. 315 Virchow describes as ochronosis a peculiar black coloration of almost all the cartilages and ligaments of the..joints of the synovial membranes.

1906 Lancet 6 Jan. 26/1 The urine of his patient.., who had the blackening of cartilages which constitutes ochronosis, was brown when passed.

1948 W. A. D. Anderson Pathology iv. 88 Phenol poisoning, due to absorption of phenol from surgical dressings, has been reported to cause a pigmentation similar to ochronosis.

1962 C. A. Clarke Genetics for Clinician xiii. 156 Alkaptonuria... In addition to the urinary abnormality..there is pigmentation of cartilage and ligaments (ochronosis).

1970 Nature 21 Nov. 770/1 Adults with alcaptonuria develop a destructive arthritis secondary to the deposition of a melanin-like pigment in their connective tissues, especially skin, tendon and cartilage (ochronosis).

1987 D. J. Weatherall et al. Oxf. Textbk. Med. (ed. 2) I. ix. 20/1 An acquired form of ochronosis was formerly encountered in patients in whom phenol dressings were applied to chronic cutaneous ulcers.

Derivatives

ochroˈnotic adj.

ΘΚΠ

the world > health and disease > ill health > a disease > diseases of tissue > [adjective] > abnormal pigmentation

melanic1822

melanose1823

ochronotic1922

hyperpigmented1956

1922 Arch. Internal Med. 29 737 Hanseman observed diffuse and granular ochronotic pigment in the tissues.

1961 Arthritis & Rheumatism 4 137 (title) Studies on the pathogenesis of ochronotic arthropathy.

1977 Science 5 Aug. 566 (title) Biochemical identification of homogentisic acid pigment in an ochronotic Egyptian mummy.

2002 Rheumatol. Internat. 21 205 Ochronotic arthropathy is the musculoskeletal manifestation of alkaptonuria.

This entry has been updated (OED Third Edition, March 2004; most recently modified version published online March 2022).

单词	ochronosis
释义	ochronosisn. Brit. /ˌəʊkrə(ʊ)ˈnəʊsɪs/, U.S. /ˌoʊkrəˈnoʊsəs/ Origin: A borrowing from German. Etymon: German Ochronosis. Etymology: < German Ochronosis (R. Virchow 1866, in Arch. f. path. Anat. u. Physiol. 37 218; now usually Ochronose ) < ancient Greek ὠχρός pale yellow (see ochre n.) + νόσος disease (see noso- comb. form) + -osis -osis suffix. Medicine. Abnormal brown pigmentation of tissue (esp. cartilage and ligaments), spec. that resulting from the accumulation of a melanin-like pigment derived from homogentisic acid in the metabolic disorder alkaptonuria. ΘΚΠ the world > health and disease > ill health > a disease > diseases of tissue > [noun] > abnormal pigmentation melanosis1821 ochronosis1867 polychromia1897 1867 Half-yearly Abstr. Med. Sci. 65 28 Virchow proposes to call this affection ochronosis. 1876 J. Van Duyn & E. C. Seguin tr. E. L. Wagner Man. Gen. Pathol. 315 Virchow describes as ochronosis a peculiar black coloration of almost all the cartilages and ligaments of the..joints of the synovial membranes. 1906 Lancet 6 Jan. 26/1 The urine of his patient.., who had the blackening of cartilages which constitutes ochronosis, was brown when passed. 1948 W. A. D. Anderson Pathology iv. 88 Phenol poisoning, due to absorption of phenol from surgical dressings, has been reported to cause a pigmentation similar to ochronosis. 1962 C. A. Clarke Genetics for Clinician xiii. 156 Alkaptonuria... In addition to the urinary abnormality..there is pigmentation of cartilage and ligaments (ochronosis). 1970 Nature 21 Nov. 770/1 Adults with alcaptonuria develop a destructive arthritis secondary to the deposition of a melanin-like pigment in their connective tissues, especially skin, tendon and cartilage (ochronosis). 1987 D. J. Weatherall et al. Oxf. Textbk. Med. (ed. 2) I. ix. 20/1 An acquired form of ochronosis was formerly encountered in patients in whom phenol dressings were applied to chronic cutaneous ulcers. Derivatives ochroˈnotic adj. ΘΚΠ the world > health and disease > ill health > a disease > diseases of tissue > [adjective] > abnormal pigmentation melanic1822 melanose1823 ochronotic1922 hyperpigmented1956 1922 Arch. Internal Med. 29 737 Hanseman observed diffuse and granular ochronotic pigment in the tissues. 1961 Arthritis & Rheumatism 4 137 (title) Studies on the pathogenesis of ochronotic arthropathy. 1977 Science 5 Aug. 566 (title) Biochemical identification of homogentisic acid pigment in an ochronotic Egyptian mummy. 2002 Rheumatol. Internat. 21 205 Ochronotic arthropathy is the musculoskeletal manifestation of alkaptonuria. This entry has been updated (OED Third Edition, March 2004; most recently modified version published online March 2022). < n.1867
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