nucleosomen.

Brit.

/ˈnjuːklɪəˌsəʊm/, U.S.

/ˈn(j)uklioʊˌsoʊm/

Origin: Formed within English, by derivation. Etymons: nucleo- comb. form, -some comb. form.

Etymology: < nucleo- comb. form + -some comb. form (see also quot. 1975 at sense 2). Compare (in different sense) French nucléosome (A. C. Hollande and G. Hollande 1931, in Comptes Rendus de la Soc. de Biol. 107 207), used for the nucleoid of a bacterial cell, and German Nukleosom (1958 or earlier), used for a chromosomal satellite.

1. Cell Biology. A small particle or body within a cell nucleus. rare. disused.

ΚΠ

1961 Amer. Midland Naturalist 65 456 The nuclear walls [of sensory cells in the lateral line system of a fish] are irregularly thickened by chromatin deposition and both acidophilic and basophilic nucleosomes, measuring 0.8 to 1.4 μ in diameter, may be seen within it.

2. Cell Biology and Biochemistry. Each of the bead-like structures occurring along the length of a eukaryotic chromosome, consisting of a histone octamer surrounded by a coiled section of DNA.

ΘΚΠ

the world > life > biology > biological processes > genetic activity > genetic components > [noun] > nucleic acid > DNA > parts of or structures occurring on

supercoil1939

nucleosome1975

1975 P. Oudet et al. in Cell 4 289/1 The fundamental structure of chromatin fibers is composed of a flexible chain of spherical particles with a diameter of 124–130 Å connected by DNA filaments. We have termed these particles ‘nucleosomes’, to evoke their nuclear origin and their resemblance to the ‘nu’ (ν) bodies described by Olins and Olins (1974).

1976 Nature 12 Aug. 533/1 Electron micrographs of suitably lysed nuclei show linear arrays of interconnected roughly spherical particles about 10 nm diameter called beads, ν-bodies, or nucleosomes.

1985 C. R. Leeson et al. Textbk. Histol. (ed. 5) i. 57/2 The nucleosome contains a double-stranded DNA fragment 140 to 200 base pairs long bound to an octameric histone core.

1990 EMBO Jrnl. 9 2911/1 The highly sensitive psoralen assay revealed that DNA replication appears to facilitate precise folding of DNA in the nucleosome.

This entry has been updated (OED Third Edition, December 2003; most recently modified version published online March 2022).

单词	nucleosome
释义	nucleosomen. Brit. /ˈnjuːklɪəˌsəʊm/, U.S. /ˈn(j)uklioʊˌsoʊm/ Origin: Formed within English, by derivation. Etymons: nucleo- comb. form, -some comb. form. Etymology: < nucleo- comb. form + -some comb. form (see also quot. 1975 at sense 2). Compare (in different sense) French nucléosome (A. C. Hollande and G. Hollande 1931, in Comptes Rendus de la Soc. de Biol. 107 207), used for the nucleoid of a bacterial cell, and German Nukleosom (1958 or earlier), used for a chromosomal satellite. 1. Cell Biology. A small particle or body within a cell nucleus. rare. disused. ΚΠ 1961 Amer. Midland Naturalist 65 456 The nuclear walls [of sensory cells in the lateral line system of a fish] are irregularly thickened by chromatin deposition and both acidophilic and basophilic nucleosomes, measuring 0.8 to 1.4 μ in diameter, may be seen within it. 2. Cell Biology and Biochemistry. Each of the bead-like structures occurring along the length of a eukaryotic chromosome, consisting of a histone octamer surrounded by a coiled section of DNA. ΘΚΠ the world > life > biology > biological processes > genetic activity > genetic components > [noun] > nucleic acid > DNA > parts of or structures occurring on supercoil1939 nucleosome1975 1975 P. Oudet et al. in Cell 4 289/1 The fundamental structure of chromatin fibers is composed of a flexible chain of spherical particles with a diameter of 124–130 Å connected by DNA filaments. We have termed these particles ‘nucleosomes’, to evoke their nuclear origin and their resemblance to the ‘nu’ (ν) bodies described by Olins and Olins (1974). 1976 Nature 12 Aug. 533/1 Electron micrographs of suitably lysed nuclei show linear arrays of interconnected roughly spherical particles about 10 nm diameter called beads, ν-bodies, or nucleosomes. 1985 C. R. Leeson et al. Textbk. Histol. (ed. 5) i. 57/2 The nucleosome contains a double-stranded DNA fragment 140 to 200 base pairs long bound to an octameric histone core. 1990 EMBO Jrnl. 9 2911/1 The highly sensitive psoralen assay revealed that DNA replication appears to facilitate precise folding of DNA in the nucleosome. This entry has been updated (OED Third Edition, December 2003; most recently modified version published online March 2022). < n.1961
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