nucleolysisn.

Brit.

/ˌnjuːklɪˈɒlᵻsɪs/, U.S.

/ˌn(j)ukliˈɑləsəs/

Origin: Formed within English, by compounding. Etymons: nucleo- comb. form, -lysis comb. form.

Etymology: < nucleo- comb. form + -lysis comb. form. Compare earlier nucleolytic adj. With sense 3, compare earlier chemonucleolysis n., and French nucléolyse (1971).

1. Pathology and Biochemistry. The disintegration, dissolution, or disruption of cell nuclei; karyolysis. Also: the breakdown of nucleic acid molecules, esp. by enzymatic activity (cf. nucleolytic adj.).

ΚΠ

1960 I. F. Henderson & W. D. Henderson Dict. Sci. Terms (ed. 7) 360/2 Nucleolysis, karyolysis.

1970 Jrnl. Pathol. 101 1 Addition of a concentrated suspension of peripheral blood leucocytes and subsequent incubation may lead to changes—clumping, adherence and nucleolysis—demonstrable microscopically.

1975 Nucleic Acids Res. 2 1579 The complexes are stable towards most denaturing agents and their component nucleic acids and proteins are resistant to nucleolysis and proteolysis respectively.

1993 Biochemistry 32 395 A procedure which involves isolation of whole cellular RNA from Escherichia coli, nucleolysis, separation of mononucleotides, [etc.].

1998 European Jrnl. Cell Biol. 77 294 (title) Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells.

2. Surgery. The destruction of a nucleus in the central nervous system. rare.

ΚΠ

1966 Surg. Forum 17 419 (title) Spinal V nucleolysis: intractable craniofacial pain.

3. Surgery and Medicine. Destruction of the nucleus pulposus of an intervertebral disc, esp. by the injection of an enzyme or chemical. Cf. earlier chemonucleolysis n.

ΚΠ

1980 Nouvelle Presse Médicale 9 227/1 The treatment of lumbosciatica by intra-discal injection of proteolytic enzymes (nucleolysis).

1991 Mt. Sinai Jrnl. Med. 58 159 Endoscopic laser nucleolysis, currently under investigation, may also enhance existing technological achievement in the field of minimal-intervention spinal surgery.

1996 Neurosurg. Clinics N. Amer. 7 17 At present, of all percutaneous methods, lumbar chymopapain nucleolysis is the only procedure that has withstood the test of time.

2002 Ultrasound in Med. & Biol. 28 1189 (title) Ultrasound nucleolysis: an in vitro study.

This is a new entry (OED Third Edition, December 2003; most recently modified version published online March 2022).

单词	nucleolysis
释义	nucleolysisn. Brit. /ˌnjuːklɪˈɒlᵻsɪs/, U.S. /ˌn(j)ukliˈɑləsəs/ Origin: Formed within English, by compounding. Etymons: nucleo- comb. form, -lysis comb. form. Etymology: < nucleo- comb. form + -lysis comb. form. Compare earlier nucleolytic adj. With sense 3, compare earlier chemonucleolysis n., and French nucléolyse (1971). 1. Pathology and Biochemistry. The disintegration, dissolution, or disruption of cell nuclei; karyolysis. Also: the breakdown of nucleic acid molecules, esp. by enzymatic activity (cf. nucleolytic adj.). ΚΠ 1960 I. F. Henderson & W. D. Henderson Dict. Sci. Terms (ed. 7) 360/2 Nucleolysis, karyolysis. 1970 Jrnl. Pathol. 101 1 Addition of a concentrated suspension of peripheral blood leucocytes and subsequent incubation may lead to changes—clumping, adherence and nucleolysis—demonstrable microscopically. 1975 Nucleic Acids Res. 2 1579 The complexes are stable towards most denaturing agents and their component nucleic acids and proteins are resistant to nucleolysis and proteolysis respectively. 1993 Biochemistry 32 395 A procedure which involves isolation of whole cellular RNA from Escherichia coli, nucleolysis, separation of mononucleotides, [etc.]. 1998 European Jrnl. Cell Biol. 77 294 (title) Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells. 2. Surgery. The destruction of a nucleus in the central nervous system. rare. ΚΠ 1966 Surg. Forum 17 419 (title) Spinal V nucleolysis: intractable craniofacial pain. 3. Surgery and Medicine. Destruction of the nucleus pulposus of an intervertebral disc, esp. by the injection of an enzyme or chemical. Cf. earlier chemonucleolysis n. ΚΠ 1980 Nouvelle Presse Médicale 9 227/1 The treatment of lumbosciatica by intra-discal injection of proteolytic enzymes (nucleolysis). 1991 Mt. Sinai Jrnl. Med. 58 159 Endoscopic laser nucleolysis, currently under investigation, may also enhance existing technological achievement in the field of minimal-intervention spinal surgery. 1996 Neurosurg. Clinics N. Amer. 7 17 At present, of all percutaneous methods, lumbar chymopapain nucleolysis is the only procedure that has withstood the test of time. 2002 Ultrasound in Med. & Biol. 28 1189 (title) Ultrasound nucleolysis: an in vitro study. This is a new entry (OED Third Edition, December 2003; most recently modified version published online March 2022). < n.1960
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