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单词 nonsense mutation
释义

> as lemmas

nonsense mutation
3. Molecular Biology. Of a codon: not specifying an amino acid; (of a mutation) giving rise to such a codon (and so perhaps bringing about premature termination of the synthesis of a polypeptide). Frequently in nonsense codon, nonsense mutation.
ΚΠ
1957 F. H. C. Crick et al. in Proc. National Acad. Sci. U.S.A. 43 418 We shall assume that there are certain sequences of three nucleotides with which an amino acid can be associated and certain others for which this is not possible. Using the metaphors of coding, we say that some of the 64 triplets make sense and some make nonsense.]
1961 Ann. Rev. Biochem. 30 651 An alteration in any base pair by a mutagen raises the possibility of a class of so-called nonsense mutations.
1964 G. H. Haggis et al. Introd. Molecular Biol. xii. 318 They then calculated that the sixty-four triplets could be divided..into two classes, with twenty meaningful triplets in one class and forty-four nonsense triplets in the other.
1974 Encycl. Brit. Micropædia IV. 464/2 It is now known that there may be several codes for one amino acid and that there are nonsense codes that do not code anything.
1992 Cambr. Encycl. Human Evol. (1994) i. i. 12/3 If the mutation is to a stop codon, such as UGA, then the growing amino acid chain will be cut off—a nonsense mutation.
extracted from nonsensen.adj.
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