non-nucleosideadj.n.

Brit.

/nɒnˈnjuːklɪə(ʊ)ˌsʌɪd/, U.S.

/nɑ(n)ˈn(j)ukliəˌsaɪd/

Origin: Formed within English, by derivation. Etymons: non- prefix, nucleoside n.

Etymology: < non- prefix + nucleoside n.

Biochemistry and Pharmacology.

A. adj.

That is not a nucleoside; spec. designating drugs that inhibit retroviral reverse transcriptase but are not nucleoside analogues, used in the treatment of HIV infection.

ΚΠ

1987 Molecular & Cellular Biochem. 77 187 The synthetic nucleoside, ribavirin..and mycophenolic acid, a non-nucleoside inhibitor of inosinate (IMP) dehydrogenase, are effective inducers of terminal differentiation of Friend virus transformed murine erythroleukemia cells.

1990 Science 28 Sept. 1542/1 A number of new types of non-nucleoside compounds have recently been reported to be active against HIV in vitro.

1996 AIDS 10 635 Nevirapine is a non-nucleoside reverse transcriptase inhibitor of HIV-1 which exhibits synergy in vitro with zidovudine.

2002 Washington Post 26 Feb. (Home ed.) a2/5 Researchers here also heard about the early success of a drug specifically designed to avoid resistance problems encountered by nevirapine and efavirenz, the two existing members in its class of drugs, known as non-nucleoside reverse transcriptase inhibitors.

B. n.

A non-nucleoside reverse transcriptase inhibitor.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for HIV infection

dideoxycytidine1965

azidothymidine1974

dideoxyinosine1975

AZT1985

ddC1987

Retrovir1987

zidovudine1987

ddI1989

didanosine1990

nevirapine1991

zalcitabine1991

non-nucleoside1993

1993 Nature 18 Feb. 650/1 Therapy relying on inhibitors of reverse transcriptase by nucleosides..and by non-nucleosides like pyridinones or nevirapine may exert different selection pressures on this enzyme.

2001 Antiviral Res. 52 189 Severe hepatotoxicity appears in around 10% of subjects who began triple combinations including either protease inhibitors or non-nucleosides.

This is a new entry (OED Third Edition, September 2003; most recently modified version published online March 2022).

单词	non-nucleoside
释义	non-nucleosideadj.n. Brit. /nɒnˈnjuːklɪə(ʊ)ˌsʌɪd/, U.S. /nɑ(n)ˈn(j)ukliəˌsaɪd/ Origin: Formed within English, by derivation. Etymons: non- prefix, nucleoside n. Etymology: < non- prefix + nucleoside n. Biochemistry and Pharmacology. A. adj. That is not a nucleoside; spec. designating drugs that inhibit retroviral reverse transcriptase but are not nucleoside analogues, used in the treatment of HIV infection. ΚΠ 1987 Molecular & Cellular Biochem. 77 187 The synthetic nucleoside, ribavirin..and mycophenolic acid, a non-nucleoside inhibitor of inosinate (IMP) dehydrogenase, are effective inducers of terminal differentiation of Friend virus transformed murine erythroleukemia cells. 1990 Science 28 Sept. 1542/1 A number of new types of non-nucleoside compounds have recently been reported to be active against HIV in vitro. 1996 AIDS 10 635 Nevirapine is a non-nucleoside reverse transcriptase inhibitor of HIV-1 which exhibits synergy in vitro with zidovudine. 2002 Washington Post 26 Feb. (Home ed.) a2/5 Researchers here also heard about the early success of a drug specifically designed to avoid resistance problems encountered by nevirapine and efavirenz, the two existing members in its class of drugs, known as non-nucleoside reverse transcriptase inhibitors. B. n. A non-nucleoside reverse transcriptase inhibitor. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for HIV infection dideoxycytidine1965 azidothymidine1974 dideoxyinosine1975 AZT1985 ddC1987 Retrovir1987 zidovudine1987 ddI1989 didanosine1990 nevirapine1991 zalcitabine1991 non-nucleoside1993 1993 Nature 18 Feb. 650/1 Therapy relying on inhibitors of reverse transcriptase by nucleosides..and by non-nucleosides like pyridinones or nevirapine may exert different selection pressures on this enzyme. 2001 Antiviral Res. 52 189 Severe hepatotoxicity appears in around 10% of subjects who began triple combinations including either protease inhibitors or non-nucleosides. This is a new entry (OED Third Edition, September 2003; most recently modified version published online March 2022). < adj.n.1987
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