nialamiden.

Brit.

/nʌɪˈaləmʌɪd/, U.S.

/ˌnaɪˈæləˌmaɪd/

Forms: 1900s– nialamid, 1900s– nialamide.

Origin: Formed within English, by compounding. Etymons: iproniazid n., isoniazid n., amide n.

Etymology: < nia- (in iproniazid n. or isoniazid n.) + amide n., with apparently arbitrary insertion of -al- . Compare Niamid n.

Pharmacology.

A hydrazide derivative of isonicotinic acid, which is a monoamine oxidase inhibitor used (now rarely) as an antidepressant; C₁₆H₁₈N₄O₂.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > medicine for mental conditions > [noun] > antidepressant > specific drugs

Marsilid1952

iproniazid1953

levallorphan1953

imipramine1958

Tofranil1958

isocarboxazid1959

Marplan1959

Nardil1959

nialamide1959

Niamid1959

phenelzine1959

tranylcypromine1959

Parnate1960

amitriptyline1961

monoamine oxidase inhibitor1962

nortriptyline1962

protriptyline1963

MAOI1965

maprotiline1970

mianserin1970

amoxapine1971

fluoxetine1975

paroxetine1977

Prozac1985

Seroxat1985

1959 R. P. Rowe et al. in Federation Proc. (Federation Amer. Soc. Exper. Biol.) 18 441/1 Nialamide, N-Isonicotinoyl-N′-(β-[-benzyl-carboxamido]-ethyl)hydrazine, is a potent monoamine oxidase inhibitor with significant anti-depressant activity.

1959 Proc. Soc. Exper. Biol. & Med. 101 832 (title) Pharmacological studies with nialamide, a new antidepressant agent.

1971 Brit. Med. Bull. 27 28/2 First nialamide..and then tranylcypromine..began to be used for the treatment of depression.

1992 Biol. Psychiatry 32 1042 In both experiments the excretion [of bufotenin] rose well above the values measured from the same test subject when not taking nialamide.

2000 Amino Acids 19 275 Deprenyl, but not the non-selective monoamine oxidase inhibitor nialamide, also prevent [sic] quinolinic acid-induced damage.

This entry has been updated (OED Third Edition, September 2003; most recently modified version published online March 2022).

单词	nialamide
释义	nialamiden. Brit. /nʌɪˈaləmʌɪd/, U.S. /ˌnaɪˈæləˌmaɪd/ Forms: 1900s– nialamid, 1900s– nialamide. Origin: Formed within English, by compounding. Etymons: iproniazid n., isoniazid n., amide n. Etymology: < nia- (in iproniazid n. or isoniazid n.) + amide n., with apparently arbitrary insertion of -al- . Compare Niamid n. Pharmacology. A hydrazide derivative of isonicotinic acid, which is a monoamine oxidase inhibitor used (now rarely) as an antidepressant; C₁₆H₁₈N₄O₂. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > medicine for mental conditions > [noun] > antidepressant > specific drugs Marsilid1952 iproniazid1953 levallorphan1953 imipramine1958 Tofranil1958 isocarboxazid1959 Marplan1959 Nardil1959 nialamide1959 Niamid1959 phenelzine1959 tranylcypromine1959 Parnate1960 amitriptyline1961 monoamine oxidase inhibitor1962 nortriptyline1962 protriptyline1963 MAOI1965 maprotiline1970 mianserin1970 amoxapine1971 fluoxetine1975 paroxetine1977 Prozac1985 Seroxat1985 1959 R. P. Rowe et al. in Federation Proc. (Federation Amer. Soc. Exper. Biol.) 18 441/1 Nialamide, N-Isonicotinoyl-N′-(β-[-benzyl-carboxamido]-ethyl)hydrazine, is a potent monoamine oxidase inhibitor with significant anti-depressant activity. 1959 Proc. Soc. Exper. Biol. & Med. 101 832 (title) Pharmacological studies with nialamide, a new antidepressant agent. 1971 Brit. Med. Bull. 27 28/2 First nialamide..and then tranylcypromine..began to be used for the treatment of depression. 1992 Biol. Psychiatry 32 1042 In both experiments the excretion [of bufotenin] rose well above the values measured from the same test subject when not taking nialamide. 2000 Amino Acids 19 275 Deprenyl, but not the non-selective monoamine oxidase inhibitor nialamide, also prevent [sic] quinolinic acid-induced damage. This entry has been updated (OED Third Edition, September 2003; most recently modified version published online March 2022). < n.1959
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