neocarzinostatinn.

Brit.

/ˌniːə(ʊ)ˌkɑːzɪnə(ʊ)ˈstatɪn/, U.S.

/ˈˌnioʊˌkɑrzənəˈstætn/

Origin: Formed within English, by compounding. Etymons: neo- comb. form, English carzinostatin.

Etymology: < neo- comb. form + carzinostatin, an antineoplastic substance isolated from a Streptomyces strain (J. Shōji 1961, in Jrnl. Antibiotics A. 14 27) < carzino- (alteration of carcino- in carcinoma n.) + -stat (in static adj.) + -in suffix¹. Compare scientific Latin carzinostaticus, specific epithet of Streptomyces carzinostaticus (invalidly published c1960).

Pharmacology.

A compound with antibiotic and antineoplastic properties, obtained from a strain of Streptomyces bacteria (sometimes called Streptomyces carzinostaticus), and consisting of a sulphur-containing apoprotein with a non-protein chromophore group that binds to and cleaves double-stranded DNA.The chromophore group of neocarzinostatin is an enediyne, containing a carbon-carbon double bond flanked by two carbon-carbon triple bonds.

ΚΠ

1965 Jrnl. Antibiotics A. 18 223 Neocarzinostatin is a new antibiotic from culture filtrate of Streptomyces carzinostaticus F-41.

1985 Cancer Res. 45 4224 The antitumor antibiotic neocarzinostatin (NCS)..produces single-strand breaks in mammalian cell DNA in vivo.

1992 New Scientist 20 June 16/1 Natural enediynes were first identified in 1985 by Kiyoto Edo... The first one, dubbed neocarzinostatin chromophore was extracted from neocarzinostatin, a polypeptide known to have anticancer activity.

1999 New Scientist 9 Jan. 19/1 This is the main enzyme that repairs damage inflicted on cancer cells' DNA by bleomycin, cisplatin and neocarzinostatin, chemotherapy's ‘heavy guns’.

This is a new entry (OED Third Edition, September 2003; most recently modified version published online March 2022).

单词	neocarzinostatin
释义	neocarzinostatinn. Brit. /ˌniːə(ʊ)ˌkɑːzɪnə(ʊ)ˈstatɪn/, U.S. /ˈˌnioʊˌkɑrzənəˈstætn/ Origin: Formed within English, by compounding. Etymons: neo- comb. form, English carzinostatin. Etymology: < neo- comb. form + carzinostatin, an antineoplastic substance isolated from a Streptomyces strain (J. Shōji 1961, in Jrnl. Antibiotics A. 14 27) < carzino- (alteration of carcino- in carcinoma n.) + -stat (in static adj.) + -in suffix¹. Compare scientific Latin carzinostaticus, specific epithet of Streptomyces carzinostaticus (invalidly published c1960). Pharmacology. A compound with antibiotic and antineoplastic properties, obtained from a strain of Streptomyces bacteria (sometimes called Streptomyces carzinostaticus), and consisting of a sulphur-containing apoprotein with a non-protein chromophore group that binds to and cleaves double-stranded DNA.The chromophore group of neocarzinostatin is an enediyne, containing a carbon-carbon double bond flanked by two carbon-carbon triple bonds. ΚΠ 1965 Jrnl. Antibiotics A. 18 223 Neocarzinostatin is a new antibiotic from culture filtrate of Streptomyces carzinostaticus F-41. 1985 Cancer Res. 45 4224 The antitumor antibiotic neocarzinostatin (NCS)..produces single-strand breaks in mammalian cell DNA in vivo. 1992 New Scientist 20 June 16/1 Natural enediynes were first identified in 1985 by Kiyoto Edo... The first one, dubbed neocarzinostatin chromophore was extracted from neocarzinostatin, a polypeptide known to have anticancer activity. 1999 New Scientist 9 Jan. 19/1 This is the main enzyme that repairs damage inflicted on cancer cells' DNA by bleomycin, cisplatin and neocarzinostatin, chemotherapy's ‘heavy guns’. This is a new entry (OED Third Edition, September 2003; most recently modified version published online March 2022). < n.1965
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