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单词 neuromodulator
释义

neuromodulatorn.

Brit. /ˌnjʊərə(ʊ)ˈmɒdjᵿleɪtə/, /ˌnjʊərə(ʊ)ˈmɒdʒᵿleɪtə/, U.S. /ˌn(j)ʊroʊˈmɑdʒəˌleɪdər/
Origin: Formed within English, by compounding. Etymons: neuro- comb. form, modulator n.
Etymology: < neuro- comb. form + modulator n.
Physiology.
Any substance that modifies neurotransmission or neuronal or neural activity.
ΚΠ
1967 Science 17 Feb. 878/3 Attention was focused primarily upon the catecholamines, noradrenaline and dopamine, and upon the indoleamine serotonin, chemicals believed to serve as neurotransmitters or neuromodulators of the central sympathetic nervous system.
1979 Nature 15 Mar. 256/2 There is much interest in the possibility that substance P acts as a neurotransmitter and/or a neuromodulator at certain sites in the central and peripheral nervous system.
1983 Science 2 Dec. 976/1 The term ‘neuromodulator’ has been used to refer to substances with nonclassical transmitter actions. However, there is no consensus on such a definition, and the term has been used to define peptide actions when they (i) modify the known actions of the so-called ‘classical’ neurotransmitters, (ii) act to block the release of a given neurotransmitter via their release at presynaptic endings on the terminals releasing that transmitter, or (iii) alter the turnover of other neurotransmitters.
1989 Adverse Drug Reactions & Acute Poisoning Rev. 8 4 These appear to act as neuromodulators, influencing the activity of the released monoamines and their interactions with other neurones.
1998 Parabola Fall 85/2 The changes in connectivity patterns of retinal cells are mediated by various neuromodulators within the retina, including dopamine.

Derivatives

neuromoduˈlatory adj. of, relating to, or exhibiting modification of neurotransmission or neuronal or neural activity.
ΚΠ
1967 Science 17 Feb. 851/3 Reserpine acts physiologically by depleting stores of catecholamines and serotonin—substances thought to serve neurotransmitter or neuromodulatory functions.
2001 Nature 17 May 308/1 Consistent with animal models of the amygdala's role in supporting perceptual vigilance, our findings indicate that neuromodulatory influences of the human amygdala may not be restricted to episodic memory consolidation.
This is a new entry (OED Third Edition, September 2003; most recently modified version published online March 2022).
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n.1967
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