nalorphinen.

Brit.

/nəˈlɔːfiːn/, U.S.

/nəˈlɔrˌfin/

Origin: Formed within English, by clipping or shortening. Etymon: English N-allylnormorphine.

Etymology: Shortened < N-allylnormorphine, an alternative name for the compound (see quot. 1953).

Pharmacology.

A synthetic opioid similar to morphine in chemical structure, which acts as a mixed opioid antagonist and agonist and formerly was used in the diagnosis and treatment of narcotic abuse and overdosage; (−)-(5R,6S)-9a-allyl-4,5-epoxymorphin-7-en-3,6-diol, C₁₉H₂₁NO₃.A proprietary name for this drug in the United States is Nalline n.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > antidote > [noun] > narcotic antagonists

Nalline1952

nalorphine1953

naloxone1964

naltrexone1973

1953 Jrnl. Pharmacol. & Exper. Therapeutics 109 157 N-allylnormorphine (nalorphine) has been shown to have a specific respiratory stimulating effect against the depression caused by morphine,..codeine, methadone.

1967 Martindale's Extra Pharmacopoeia (ed. 25) 838 Given apart from narcotics, nalorphine may itself cause respiratory depression and disturbing psychotic effects.

1968 J. H. Jaffe in D. H. Efron Psychopharmacol. viii. 854/1 Nalorphine has virtually no abuse potential; its subjective effects are not ‘liked’ by post-addicts; it does not relieve morphine withdrawal symptoms, but instead precipitates them.

1971 H. W. Elliott in D. H. Clouet Narcotic Drugs xxvi. 484 The pharmacological basis for the nalorphine test is an antagonism between nalorphine and the morphine-like drugs, which can be detected by examining the pupil.

1981 M. C. Gerald Pharmacol. (ed. 2) xiii. 263 In 1978, nalorphine was withdrawn from the U.S. market and replaced by naloxone.

1994 Jrnl. Pharmacol. & Exper. Therapeutics 268 47 Nalorphine did not have analgesic effects, but it antagonized analgesic effects of several other compounds.

2002 Psychopharmacology 160 170 Enadoline, bremazocine and nalorphine were less effective than spiradoline in producing antinociception.

This entry has been updated (OED Third Edition, June 2003; most recently modified version published online March 2022).

单词	nalorphine
释义	nalorphinen. Brit. /nəˈlɔːfiːn/, U.S. /nəˈlɔrˌfin/ Origin: Formed within English, by clipping or shortening. Etymon: English N-allylnormorphine. Etymology: Shortened < N-allylnormorphine, an alternative name for the compound (see quot. 1953). Pharmacology. A synthetic opioid similar to morphine in chemical structure, which acts as a mixed opioid antagonist and agonist and formerly was used in the diagnosis and treatment of narcotic abuse and overdosage; (−)-(5R,6S)-9a-allyl-4,5-epoxymorphin-7-en-3,6-diol, C₁₉H₂₁NO₃.A proprietary name for this drug in the United States is Nalline n. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > antidote > [noun] > narcotic antagonists Nalline1952 nalorphine1953 naloxone1964 naltrexone1973 1953 Jrnl. Pharmacol. & Exper. Therapeutics 109 157 N-allylnormorphine (nalorphine) has been shown to have a specific respiratory stimulating effect against the depression caused by morphine,..codeine, methadone. 1967 Martindale's Extra Pharmacopoeia (ed. 25) 838 Given apart from narcotics, nalorphine may itself cause respiratory depression and disturbing psychotic effects. 1968 J. H. Jaffe in D. H. Efron Psychopharmacol. viii. 854/1 Nalorphine has virtually no abuse potential; its subjective effects are not ‘liked’ by post-addicts; it does not relieve morphine withdrawal symptoms, but instead precipitates them. 1971 H. W. Elliott in D. H. Clouet Narcotic Drugs xxvi. 484 The pharmacological basis for the nalorphine test is an antagonism between nalorphine and the morphine-like drugs, which can be detected by examining the pupil. 1981 M. C. Gerald Pharmacol. (ed. 2) xiii. 263 In 1978, nalorphine was withdrawn from the U.S. market and replaced by naloxone. 1994 Jrnl. Pharmacol. & Exper. Therapeutics 268 47 Nalorphine did not have analgesic effects, but it antagonized analgesic effects of several other compounds. 2002 Psychopharmacology 160 170 Enadoline, bremazocine and nalorphine were less effective than spiradoline in producing antinociception. This entry has been updated (OED Third Edition, June 2003; most recently modified version published online March 2022). < n.1953
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