myelinolysisn.

Brit.

/ˌmʌɪᵻlᵻˈnɒlᵻsɪs/, U.S.

/ˈˌmaɪələˈnɑləsəs/

Inflections: Plural myelinolyses.

Origin: Formed within English, by compounding. Etymons: myelino- comb. form, -lysis comb. form.

Etymology: < myelino- comb. form + -lysis comb. form.

Medicine and Pathology.

Dissolution or destruction of the myelin sheath of nerve fibres; spec. demyelination of the pons or other areas of the brain, typically associated with chronic alcoholism, electrolyte imbalance (esp. hyponatraemia and its correction), and liver transplantation (chiefly in central pontine myelinolysis).

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of internal organs > disorders of nervous system > [noun] > disorders of brain > other brain disorders

brain damage1864

mind-blindness1888

satellitosis1906

syringobulbia1908

Alzheimer's disease1911

kernicterus1912

pseudotumour1914

brain death1928

punch-drunk1928

Sturge–Weber syndrome1935

Alzheimer1938

Creutzfeldt–Jakob1939

Alzheimer1940

Schilder's disease1940

hypsarrhythmia1952

kuru1957

laughing death1957

Minamata disease1957

myelinolysis1959

spongiform encephalopathy1960

CJD1975

old-timer's disease1983

mad —— disease1990

1959 R. D. Adams et al. in A.M.A. Arch. Neurol. & Psychiatry (Chicago) 81 171/2 Because of the unique clinical and pathologic features of the disease which we have described, we believe it should be given a specific name. The term central pontine myelinolysis was chosen because it denotes both the specific anatomic localization of this disease and the remarkable unsystematic dissolution of medullated fibers.

1971 U. K. Le Guin Lathe of Heaven (1973) ii. 14 Extreme alcoholism can lead to a condition called central pontine myelinolysis, which is fatal.

1978 Adv. Exper. Med. & Biol. 100 365 The general observation that myelin destruction in inflammatory lesions begins prior to phagocytosis suggests a common mechanism for myelinolysis in these diseases.

1993 Amer. Jrnl. Neuroradiol. 14 163 Osmotic myelinolysis is a distinctive clinical syndrome with characteristic MR [= magnetic resonance] features in the central pons (central pontine myelinolysis) and in other locations (extrapontine myelinolysis).

2000 Curr. Opinion Neurol. 13 691 The separation of patients with myelinolysis in central pontine and extrapontine locations is possible on the basis of clinical symptoms.

This is a new entry (OED Third Edition, June 2003; most recently modified version published online March 2022).

单词	myelinolysis
释义	myelinolysisn. Brit. /ˌmʌɪᵻlᵻˈnɒlᵻsɪs/, U.S. /ˈˌmaɪələˈnɑləsəs/ Inflections: Plural myelinolyses. Origin: Formed within English, by compounding. Etymons: myelino- comb. form, -lysis comb. form. Etymology: < myelino- comb. form + -lysis comb. form. Medicine and Pathology. Dissolution or destruction of the myelin sheath of nerve fibres; spec. demyelination of the pons or other areas of the brain, typically associated with chronic alcoholism, electrolyte imbalance (esp. hyponatraemia and its correction), and liver transplantation (chiefly in central pontine myelinolysis). ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > disorders of nervous system > [noun] > disorders of brain > other brain disorders brain damage1864 mind-blindness1888 satellitosis1906 syringobulbia1908 Alzheimer's disease1911 kernicterus1912 pseudotumour1914 brain death1928 punch-drunk1928 Sturge–Weber syndrome1935 Alzheimer1938 Creutzfeldt–Jakob1939 Alzheimer1940 Schilder's disease1940 hypsarrhythmia1952 kuru1957 laughing death1957 Minamata disease1957 myelinolysis1959 spongiform encephalopathy1960 CJD1975 old-timer's disease1983 mad —— disease1990 1959 R. D. Adams et al. in A.M.A. Arch. Neurol. & Psychiatry (Chicago) 81 171/2 Because of the unique clinical and pathologic features of the disease which we have described, we believe it should be given a specific name. The term central pontine myelinolysis was chosen because it denotes both the specific anatomic localization of this disease and the remarkable unsystematic dissolution of medullated fibers. 1971 U. K. Le Guin Lathe of Heaven (1973) ii. 14 Extreme alcoholism can lead to a condition called central pontine myelinolysis, which is fatal. 1978 Adv. Exper. Med. & Biol. 100 365 The general observation that myelin destruction in inflammatory lesions begins prior to phagocytosis suggests a common mechanism for myelinolysis in these diseases. 1993 Amer. Jrnl. Neuroradiol. 14 163 Osmotic myelinolysis is a distinctive clinical syndrome with characteristic MR [= magnetic resonance] features in the central pons (central pontine myelinolysis) and in other locations (extrapontine myelinolysis). 2000 Curr. Opinion Neurol. 13 691 The separation of patients with myelinolysis in central pontine and extrapontine locations is possible on the basis of clinical symptoms. This is a new entry (OED Third Edition, June 2003; most recently modified version published online March 2022). < n.1959
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