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单词 muscimol
释义

muscimoln.

Brit. /ˈmʌskɪmɒl/, /ˈmʌsɪmɒl/, U.S. /ˈməsəˌmɑl/, /ˈməsəˌmɔl/
Origin: A borrowing from German. Etymon: German Muscimol.
Etymology: < German Muscimol (G. F. R. Muller and C. H. Engster 1965, in Helvetica Chimica Acta 48 910) < musc- (in scientific Latin muscarius , specific epithet of Amanita muscaria: see muscarine n.) + im- (in German Imin imine n.) + -ol -ol suffix.
Biochemistry.
An alkaloid with hallucinogenic and narcotic properties which is an analogue of gamma-aminobutyric acid and occurs naturally in the fly agaric ( Amanita muscaria) and certain other fungi; 3-hydroxy-5-aminomethylisoxazole, C4H6N2O2. Cf. muscarine n.
ΘΚΠ
the world > physical sensation > use of drugs and poison > an intoxicating drug > [noun] > hallucinogenic drug > other hallucinogenic drugs
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muscimol1967
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1967 P. G. Waser in D. H. Efron et al. Ethnopharmacol. Search for Psychoactive Drugs 427 The narcosis potentiating principle of the mushroom consists of three different compounds... Sedative action of muscazon was much less than with ibotenic acid and muscimol.
1981 Sci. Amer. Feb. 23/1 The medical texts often advise atropine as an antidote; it is indeed a specific against the absent muscarine, but it may enhance the effects of the actual hallucinogen, the alkaloid muscimol.
1990 Jrnl. Neuroendocrinol. 6 871/1 Microinjection of the γ-aminobutyric acid (GABA) agonist, muscimol, also blocks vasopressin release in response to haemorrhage.
This is a new entry (OED Third Edition, March 2003; most recently modified version published online March 2022).
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n.1967
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