monoclonaladj.n.

Brit.

/ˌmɒnə(ʊ)ˈkləʊnl/, U.S.

/ˌmɑnəˈkloʊn(ə)l/

Origin: Formed within English, by compounding. Etymons: mono- comb. form, clonal adj.

Etymology: < mono- comb. form + clonal adj. Compare polyclonal adj. and n.

Biology and Medicine.

A. adj.

Forming a clone derived asexually from a single individual or cell; relating to, involving, or produced by such a clone.

ΘΚΠ

the world > life > biology > biological processes > genetic activity > heredity or hereditary descent > [adjective] > descent from common ancestor > clone or polyclone

monoclonal1914

polyclonal1914

cloned1933

clonal1946

1914 W. E. Agar in Philos. Trans. (Royal Soc.) B. 205 422 When a population is known to have been descended asexually from a single common ancestor, it consists of a single clone and may be described as monoclonal.

1963 Science 14 June 1218/1 This work [on myeloma proteins] has been extended to include ‘monoclonal’ γ-globulins appearing in smaller amounts in certain presumed normal individuals.

1984 M. J. Taussig Processes in Pathol. & Microbiol. (ed. 2) ii. 97 Both in myeloma-associated amyloidosis and in so-called primary amyloidosis, where there is no overt underlying disease, the protein deposited in the tissues consists of part or all of a homogeneous (monoclonal) Ig light chain called AL protein.

2000 Brit. Jrnl. Haematol. 108 549 The number of these monoclonal cells was significantly increased in patients in an advanced stage of MM [= multiple myeloma].

B. n.

Short for monoclonal antibody n. at Compounds.

ΘΚΠ

the world > life > biology > substance > process stimulators or inhibitors > antibody > [noun] > types of

Russell body1892

precipitin1900

nephrotoxin1902

hepatotoxin1903

opsonin1903

autoantibody1905

concanavalin1917

isoantibody1919

reagin1925

immune globulin1934

macroglobulin1952

immunoglobulin1953

properdin1954

LATS1961

alloantibody1964

xenoantibody1974

monoclonal1980

abzyme1986

1980 Sci. Amer. Oct. 60/3 As monoclonals become available they are therefore likely to supersede conventional antibodies in many investigative and clinical laboratories.

2000 Jrnl. Internal Med. 247 385 The antibodies were used to analyse the cross-reactivity between monoclonals with different specificities.

Compounds

monoclonal antibody n. an antibody produced by a single clone of cells and having a unique antigenic specificity; (now) esp. an antibody preparation synthesized by a hybridoma; abbreviated MAB.

ΚΠ

1967 Proc. National Acad. Sci. U.S.A. 57 1495 It seems likely..that many other instances of monoclonal antibodies can be found.

1984 Sci. Amer. Dec. 64/1 Monoclonal antibodies have become standard tools for finding, identifying and isolating particular molecules in complex mixtures or in tissues.

2000 U.S. News & World Rep. 8 May 52/1 She tried an ‘anti-IgE’ drug, a monoclonal antibody designed to hobble immunoglobulin E.

This is a new entry (OED Third Edition, December 2002; most recently modified version published online March 2022).

单词	monoclonal
释义	monoclonaladj.n. Brit. /ˌmɒnə(ʊ)ˈkləʊnl/, U.S. /ˌmɑnəˈkloʊn(ə)l/ Origin: Formed within English, by compounding. Etymons: mono- comb. form, clonal adj. Etymology: < mono- comb. form + clonal adj. Compare polyclonal adj. and n. Biology and Medicine. A. adj. Forming a clone derived asexually from a single individual or cell; relating to, involving, or produced by such a clone. ΘΚΠ the world > life > biology > biological processes > genetic activity > heredity or hereditary descent > [adjective] > descent from common ancestor > clone or polyclone monoclonal1914 polyclonal1914 cloned1933 clonal1946 1914 W. E. Agar in Philos. Trans. (Royal Soc.) B. 205 422 When a population is known to have been descended asexually from a single common ancestor, it consists of a single clone and may be described as monoclonal. 1963 Science 14 June 1218/1 This work [on myeloma proteins] has been extended to include ‘monoclonal’ γ-globulins appearing in smaller amounts in certain presumed normal individuals. 1984 M. J. Taussig Processes in Pathol. & Microbiol. (ed. 2) ii. 97 Both in myeloma-associated amyloidosis and in so-called primary amyloidosis, where there is no overt underlying disease, the protein deposited in the tissues consists of part or all of a homogeneous (monoclonal) Ig light chain called AL protein. 2000 Brit. Jrnl. Haematol. 108 549 The number of these monoclonal cells was significantly increased in patients in an advanced stage of MM [= multiple myeloma]. B. n. Short for monoclonal antibody n. at Compounds. ΘΚΠ the world > life > biology > substance > process stimulators or inhibitors > antibody > [noun] > types of Russell body1892 precipitin1900 nephrotoxin1902 hepatotoxin1903 opsonin1903 autoantibody1905 concanavalin1917 isoantibody1919 reagin1925 immune globulin1934 macroglobulin1952 immunoglobulin1953 properdin1954 LATS1961 alloantibody1964 xenoantibody1974 monoclonal1980 abzyme1986 1980 Sci. Amer. Oct. 60/3 As monoclonals become available they are therefore likely to supersede conventional antibodies in many investigative and clinical laboratories. 2000 Jrnl. Internal Med. 247 385 The antibodies were used to analyse the cross-reactivity between monoclonals with different specificities. Compounds monoclonal antibody n. an antibody produced by a single clone of cells and having a unique antigenic specificity; (now) esp. an antibody preparation synthesized by a hybridoma; abbreviated MAB. ΚΠ 1967 Proc. National Acad. Sci. U.S.A. 57 1495 It seems likely..that many other instances of monoclonal antibodies can be found. 1984 Sci. Amer. Dec. 64/1 Monoclonal antibodies have become standard tools for finding, identifying and isolating particular molecules in complex mixtures or in tissues. 2000 U.S. News & World Rep. 8 May 52/1 She tried an ‘anti-IgE’ drug, a monoclonal antibody designed to hobble immunoglobulin E. This is a new entry (OED Third Edition, December 2002; most recently modified version published online March 2022). < adj.n.1914
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