monosubstitutionn.
/ˌmɒnə(ʊ)sʌbstᵻˈtjuːʃn/, /ˌmɒnə(ʊ)sʌbstᵻˈtʃuːʃn/, U.S. /ˈˌmɑnəˌsəbstəˈt(j)uʃ(ə)n/ Chemistry.
Substitution affecting only one of the atoms or positions in a molecular structure.
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monosubstitution1881
1881 H. Watts in Nature 15 Dec. 148/1 The saturated hydro-carbons..are first described; next their mono-substitution derivatives.
1922 J. J. Sudborough Bernthsen's Text-bk. Org. Chem. (new ed.) ii. 59 In the case of the higher hydrocarbons, two isomeric mono-substitution products are usually formed.
1955 B. C. L. Kemp Elem. Org. Chem. (new ed.) xvi. 228 Benzene gives rise to one mono-substitution derivative only of each type.
1992 Jrnl. Medicinal Chem. 35 431 Monosubstitution on the benzamidine rings..had no influence on the DNA-binding affinity of the compounds.
This entry has been updated (OED Third Edition, December 2002; most recently modified version published online March 2022).
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n.1881