missenseadj.

Brit.

/ˈmɪss(ə)ns/, U.S.

/ˈmɪ(s)ˌsɛns/

Origin: Formed within English, by derivation. Etymons: mis- prefix¹, sense n.

Etymology: < mis- prefix¹ + sense n., after nonsense n. 3.

Genetics.

Of, relating to, or designating a genetic mutation that alters a codon to code for a different amino acid, resulting in an amino acid substitution in the protein product of the gene; (also) designating such a codon. Cf. nonsense n. 3.

ΘΚΠ

the world > life > biology > biological processes > genetic activity > [adjective] > changes or actions of genes or chromosomes > mutation > specific quality of

leaky1955

missense1961

1961 T. C. Levinthal & P. F. Davison in Ann. Rev. Biochem. 30 651 An alteration in any base pair by a mutagen raises the possibility of a class of so-called nonsense mutations, as well as a class of missense mutations... A missense mutation in this context is one which causes a substitution of one amino acid for another at a particular position in the protein.

1974 Nature 2 Aug. 413/1 The anticodons of the suppressor tRNAs are complementary to the missense codons suppressed by these tRNAs.

1979 Nature 11 Jan. 147/1 No auxotrophic mutations in yeast are known to be missense on the basis of amino acid substitution or nucleotide sequence data.

1988 L. Stryer Biochem. (ed. 3) x. 254 These probes have also revealed that classic hemophilia is produced by many kinds of missense and chain-termination mutations in the Factor VIII gene.

1990 Nucleic Acids Res. 18 288/1 Missense and nonsense suppressors of tRNA^Thr containing anticodon base changes are inefficient suppressors in vivo.

This entry has been updated (OED Third Edition, June 2002; most recently modified version published online March 2022).

† missensev.

Forms: 1500s missence, 1500s mysense, 1500s–1600s missense.

Origin: Probably formed within English, by derivation. Etymons: mis- prefix¹, sense n.

Etymology: Probably < mis- prefix¹ + sense n. Compare later sense v., and mis-sense n. N.E.D. (1907) indicates the stress as misˈsense.

Obsolete.

transitive. To attach a wrong sense or meaning to.

ΘΚΠ

the mind > mental capacity > intelligibility > misinterpretation > misinterpret [verb (transitive)]

misunderstanda1225

mistake1402

misconstruea1425

miskenc1480

misgloze1532

misinterpret1547

missense1560

wrest1563

misdeem1570

misconceive1586

misconstruct1596

misinfer1597

misconceit1598

misknowa1600

to look beyond1600

lose1600

mismean1605

misprize1609

misread1612

misween1614

misimagine1626

misapprehend1628

construea1640

mislead1654

equivocate1665

misrender1674

misaccept1697

miscomprehend1813

misperceive1911

1560 J. Jewel Serm. A iij in J. Jewel & H. Cole True Copies Lett. The false Prophets..caused the people..to missence the sacraments.

1590 W. Clever Flower of Phisicke 60 There are many which despise Hypocrates in his Aphorismes, altogether missensing his doctrine of heate.

1628 O. Felltham Resolves: 2nd Cent. lxxi. sig. V4^v Philoxenus..hearing some Masons mis-sensing his lines,..falls to breaking their Bricks amaine: They aske the cause, and hee replyes, They spoile his worke, and he theirs.

This entry has been updated (OED Third Edition, June 2002; most recently modified version published online December 2020).

单词	missense
释义	missenseadj. Brit. /ˈmɪss(ə)ns/, U.S. /ˈmɪ(s)ˌsɛns/ Origin: Formed within English, by derivation. Etymons: mis- prefix¹, sense n. Etymology: < mis- prefix¹ + sense n., after nonsense n. 3. Genetics. Of, relating to, or designating a genetic mutation that alters a codon to code for a different amino acid, resulting in an amino acid substitution in the protein product of the gene; (also) designating such a codon. Cf. nonsense n. 3. ΘΚΠ the world > life > biology > biological processes > genetic activity > [adjective] > changes or actions of genes or chromosomes > mutation > specific quality of leaky1955 missense1961 1961 T. C. Levinthal & P. F. Davison in Ann. Rev. Biochem. 30 651 An alteration in any base pair by a mutagen raises the possibility of a class of so-called nonsense mutations, as well as a class of missense mutations... A missense mutation in this context is one which causes a substitution of one amino acid for another at a particular position in the protein. 1974 Nature 2 Aug. 413/1 The anticodons of the suppressor tRNAs are complementary to the missense codons suppressed by these tRNAs. 1979 Nature 11 Jan. 147/1 No auxotrophic mutations in yeast are known to be missense on the basis of amino acid substitution or nucleotide sequence data. 1988 L. Stryer Biochem. (ed. 3) x. 254 These probes have also revealed that classic hemophilia is produced by many kinds of missense and chain-termination mutations in the Factor VIII gene. 1990 Nucleic Acids Res. 18 288/1 Missense and nonsense suppressors of tRNA^Thr containing anticodon base changes are inefficient suppressors in vivo. This entry has been updated (OED Third Edition, June 2002; most recently modified version published online March 2022). † missensev. Forms: 1500s missence, 1500s mysense, 1500s–1600s missense. Origin: Probably formed within English, by derivation. Etymons: mis- prefix¹, sense n. Etymology: Probably < mis- prefix¹ + sense n. Compare later sense v., and mis-sense n. N.E.D. (1907) indicates the stress as misˈsense. Obsolete. transitive. To attach a wrong sense or meaning to. ΘΚΠ the mind > mental capacity > intelligibility > misinterpretation > misinterpret [verb (transitive)] misunderstanda1225 mistake1402 misconstruea1425 miskenc1480 misgloze1532 misinterpret1547 missense1560 wrest1563 misdeem1570 misconceive1586 misconstruct1596 misinfer1597 misconceit1598 misknowa1600 to look beyond1600 lose1600 mismean1605 misprize1609 misread1612 misween1614 misimagine1626 misapprehend1628 construea1640 mislead1654 equivocate1665 misrender1674 misaccept1697 miscomprehend1813 read1879 misperceive1911 1560 J. Jewel Serm. A iij in J. Jewel & H. Cole True Copies Lett. The false Prophets..caused the people..to missence the sacraments. 1590 W. Clever Flower of Phisicke 60 There are many which despise Hypocrates in his Aphorismes, altogether missensing his doctrine of heate. 1628 O. Felltham Resolves: 2nd Cent. lxxi. sig. V4^v Philoxenus..hearing some Masons mis-sensing his lines,..falls to breaking their Bricks amaine: They aske the cause, and hee replyes, They spoile his worke, and he theirs. This entry has been updated (OED Third Edition, June 2002; most recently modified version published online December 2020). > see also also refers to : † mis-sensen. < adj.1961v.1560 see also
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missenseadj.

† missensev.

> see also