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单词 mithridatism
释义

mithridatismn.

Brit. /ˈmɪθrᵻdeɪtɪz(ə)m/, /mᵻˈθrɪdətɪz(ə)m/, U.S. /ˌmɪθrəˈdeɪˌtɪz(ə)m/
Forms: 1800s mithradatism, 1800s– mithridatism. Also with capital initial.
Origin: A borrowing from French. Etymon: French Mithridatisme.
Etymology: < French Mithridatisme (1846 in the passage translated in quot. 1851) < the name of Mithridates (see mithridate n.) + -isme -ism suffix. Compare Hellenistic Greek Μιθραδατισμός act of siding with Mithridates. N.E.D. (1907) gives only the pronunciation (mi·þrideitiz'm) /ˈmɪθrɪdeɪtɪz(ə)m/.
Tolerance to the effects of a poison or toxin, spec. that (actually or supposedly) acquired by the administration of gradually increasing doses; the acquisition of such tolerance.
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mithridatism1851
1851 J. R. Morell tr. C. Fourier Passions Human Soul I. 191 The state of Mithridatism, or unitary accord of our bodies with the neuter poisons, will depend on [etc.].
1889 E. R. Lankester in Nature 13 June 149/1Mithradatism’. I am anxious to introduce the above word for the purpose of indicating the phenomenon of immunity to poison (whether of bacterial or other origin) induced by administering to an organism gradually increased doses of poison.
1921 Jrnl. Philos. 18 476 Anaphylaxia, the reverse of mithridatism, is the increased susceptibility to certain colloidal poisons.
1933 Q. Jrnl. Biol. 8 132 Mithridatism..or habituation is much less truly an immune reaction.
1955 W. Gaddis Recognitions i. i. 8 It was at that time that he developed a taste for schnapps, and started the course of mithridatism which was to serve him so well in his later years.
1992 Courier-Jrnl. (Louisville, Kentucky) (Nexis) 11 Mar. 10 a Mithridates himself lives on in the language. Mithridatism..is ‘tolerance of a poison, acquired by taking gradually larger doses of it’.
This entry has been updated (OED Third Edition, June 2002; most recently modified version published online March 2022).
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n.1851
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