misonidazolen.
/ˌmɪsə(ʊ)ˈnʌɪdəzəʊl/, U.S. /ˌmɪsəˈnaɪdəˌzɔl/, /ˌmɪsəˈnaɪdəˌzɑl/ Pharmacology.
A nitroimidazole used to radiosensitize hypoxic tumour cells and as a marker for hypoxic tissue; 3-methoxy-1-(2-nitroimidazol-1-yl) propan-2-ol, C7H11N3O4.
ΚΠ
1977 Approved Names 1973 (Brit. Pharmacopœia Comm.) Suppl. vii Misonidazole... 3-Methoxy-1-(2-nitroimidazol-1-yl) propan-2-ol... Treatment of trichomoniasis.
1978 Nature 26 Jan. 370/2 Misonidazole, an electron-affinic, nitroheterocyclic compound (1-(2-nitro-1-imidazole)-3 methoxy-2-propanol, Ro-07-0582) is undergoing preliminary clinical trials, which are exploring its capacity to sensitise hypoxic tumour cells to ionising radiation damage.
1990 Carcinogenesis 11 1407/1 Two classes of such agents were already known, i.e. quinones which could be bioreduced, e.g. mitomycin C, and the nitroimidazole hypoxic radiosensitizers, e.g. misonidazole.
1996 Jrnl. Dental Res. 75 1753 Tritiated misonidazole is a marker which preferentially labels cells with decreased oxygen tension.
This is a new entry (OED Third Edition, June 2002; most recently modified version published online March 2022).
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