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单词 mersalyl
释义

mersalyln.

Brit. /məːˈsalɪl/, /məːˈsalʌɪl/, U.S. /ˈmərsələl/
Origin: Formed within English, by derivation. Etymons: mercury n., salicyl n., -yl suffix.
Etymology: < mer- (in mercury n.) + sal- (in salicyl n.) + -yl suffix.
Pharmacology.
The sodium salt of a mercury-containing derivative of salicylamide, formerly used (often in combination with theophylline) to treat oedema, owing to its powerful diuretic properties; C13H16HgNNaO6. mersalyl acid n. the parent acid of this salt, C13H17HgNO6.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > cleansing or expelling medicines > [noun] > diuretic > specific
Haarlem oil1885
Salyrgan1924
mersalyl1936
acetazolamide1954
chlorothiazide1957
thiazide1959
triamterene1962
ethacrynic acid1963
frusemide1963
1936 Brit. Pharmacopœia 1932 Add. i. 46 (heading) Mersalyl.
1940 Jrnl. Amer. Med. Assoc. 23 Nov. 1786/1 (heading) The effect of mersalyl (Salyrgan) on plasma volume.
1958 Times 23 Apr. 15/4 He had referred to ammonium chloride as a diuretic normally used in conjunction with mersalyl.
1972 Nature 7 Apr. 301/2 Mersalyl, a potent inhibitor of myofibrillar ATPase, was without effect on the contraction induced by calcium.
1987 M. J. Neal Med. Pharmacol. at Glance xiii. 32/2 Mercurial diuretics (such as mersalyl) which are nephrotoxic..are obsolete.
1988 BioFactors 1 151/1 After reaction with mersalyl acid, the enzyme is EPR silent both in the presence and absence of CO.
This entry has been updated (OED Third Edition, September 2001; most recently modified version published online March 2022).
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n.1936
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