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单词 metoclopramide
释义

metoclopramiden.

Brit. /ˌmɛtəˈkləʊprəmʌɪd/, U.S. /ˌmɛdəˈkloʊprəˌmaɪd/
Origin: A borrowing from French. Etymon: French métoclopramide.
Etymology: < French métoclopramide (L. Justin-Besançon et al. 1964, in Comptes rendus de l'Acad. des Sciences 258 4385) < elements of the chemical name méthoxy-2 chloro-5 procaïnamide < méthoxy- methoxy- comb. form + chloro- chloro- comb. form2 + procaïnamide procainamide n.
Pharmacology.
A procainamide derivative that is a dopamine D2-receptor antagonist, given (usually as the hydrochloride) orally or by injection as an anti-emetic and stimulant of gastrointestinal motility; 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxybenzamide, C14H22ClN3O2.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > astringent or restringent preparations > [noun] > for stopping vomiting or nausea > specific drugs
Phenergan1948
Dramamine1949
promethazine1949
chlorpromazine1952
Marezine1952
Marzine1954
Thorazine1954
meclozine1955
perphenazine1957
trifluoperazine1958
metoclopramide1964
sulpiride1970
1964 Semaine des Hopitaux de Paris 14 Oct. 2345/1 An intravenous injection of ten milligrams metoclopramide produces within six minutes a gastric hyperkinesia.
1977 Lancet 19 Nov. 1088/2 Metoclopramide, an antidopaminergic drug, stimulates thyroid-stimulating hormone in hypothyroid patients and prolactin in healthy people.
1987 Brit. Med. Jrnl. 4 July 30/2 The long term use of phenothiazines, butyrophenones, and metoclopramide for dizziness, nausea, and night sedation is inappropriate and must be avoided to prevent extrapyramidal reactions.
1996 S. Lavery et al. Hamlyn Encycl. Complementary Health 326/2 For vomiting, drugs such as metoclopramide may be used, but only in extreme circumstances.
This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).
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n.1964
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