metoclopramiden.

Brit.

/ˌmɛtəˈkləʊprəmʌɪd/, U.S.

/ˌmɛdəˈkloʊprəˌmaɪd/

Origin: A borrowing from French. Etymon: French métoclopramide.

Etymology: < French métoclopramide (L. Justin-Besançon et al. 1964, in Comptes rendus de l'Acad. des Sciences 258 4385) < elements of the chemical name méthoxy-2 chloro-5 procaïnamide < méthoxy- methoxy- comb. form + chloro- chloro- comb. form² + procaïnamide procainamide n.

Pharmacology.

A procainamide derivative that is a dopamine D2-receptor antagonist, given (usually as the hydrochloride) orally or by injection as an anti-emetic and stimulant of gastrointestinal motility; 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxybenzamide, C₁₄H₂₂ClN₃O₂.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > astringent or restringent preparations > [noun] > for stopping vomiting or nausea > specific drugs

Phenergan1948

Dramamine1949

promethazine1949

chlorpromazine1952

Marezine1952

Marzine1954

Thorazine1954

meclozine1955

perphenazine1957

trifluoperazine1958

metoclopramide1964

sulpiride1970

1964 Semaine des Hopitaux de Paris 14 Oct. 2345/1 An intravenous injection of ten milligrams metoclopramide produces within six minutes a gastric hyperkinesia.

1977 Lancet 19 Nov. 1088/2 Metoclopramide, an antidopaminergic drug, stimulates thyroid-stimulating hormone in hypothyroid patients and prolactin in healthy people.

1987 Brit. Med. Jrnl. 4 July 30/2 The long term use of phenothiazines, butyrophenones, and metoclopramide for dizziness, nausea, and night sedation is inappropriate and must be avoided to prevent extrapyramidal reactions.

1996 S. Lavery et al. Hamlyn Encycl. Complementary Health 326/2 For vomiting, drugs such as metoclopramide may be used, but only in extreme circumstances.

This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).

单词	metoclopramide
释义	metoclopramiden. Brit. /ˌmɛtəˈkləʊprəmʌɪd/, U.S. /ˌmɛdəˈkloʊprəˌmaɪd/ Origin: A borrowing from French. Etymon: French métoclopramide. Etymology: < French métoclopramide (L. Justin-Besançon et al. 1964, in Comptes rendus de l'Acad. des Sciences 258 4385) < elements of the chemical name méthoxy-2 chloro-5 procaïnamide < méthoxy- methoxy- comb. form + chloro- chloro- comb. form² + procaïnamide procainamide n. Pharmacology. A procainamide derivative that is a dopamine D2-receptor antagonist, given (usually as the hydrochloride) orally or by injection as an anti-emetic and stimulant of gastrointestinal motility; 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxybenzamide, C₁₄H₂₂ClN₃O₂. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > astringent or restringent preparations > [noun] > for stopping vomiting or nausea > specific drugs Phenergan1948 Dramamine1949 promethazine1949 chlorpromazine1952 Marezine1952 Marzine1954 Thorazine1954 meclozine1955 perphenazine1957 trifluoperazine1958 metoclopramide1964 sulpiride1970 1964 Semaine des Hopitaux de Paris 14 Oct. 2345/1 An intravenous injection of ten milligrams metoclopramide produces within six minutes a gastric hyperkinesia. 1977 Lancet 19 Nov. 1088/2 Metoclopramide, an antidopaminergic drug, stimulates thyroid-stimulating hormone in hypothyroid patients and prolactin in healthy people. 1987 Brit. Med. Jrnl. 4 July 30/2 The long term use of phenothiazines, butyrophenones, and metoclopramide for dizziness, nausea, and night sedation is inappropriate and must be avoided to prevent extrapyramidal reactions. 1996 S. Lavery et al. Hamlyn Encycl. Complementary Health 326/2 For vomiting, drugs such as metoclopramide may be used, but only in extreme circumstances. This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022). < n.1964
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