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单词 mianserin
释义

mianserinn.

Brit. /mʌɪˈansərɪn/, U.S. /miˈænsərən/
Origin: Of unknown origin.
Etymology: Origin unknown; the element -anserin is perhaps < an- (in anti- prefix) + ser- and -in (in serotonin n.).
Pharmacology.
A tetracyclic antidepressant with sedative effects, given orally as the hydrochloride; 1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazino[1,2a]azepine, C18H20N2.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > medicine for mental conditions > [noun] > antidepressant > specific drugs
Marsilid1952
iproniazid1953
levallorphan1953
imipramine1958
Tofranil1958
isocarboxazid1959
Marplan1959
Nardil1959
nialamide1959
Niamid1959
phenelzine1959
tranylcypromine1959
Parnate1960
amitriptyline1961
monoamine oxidase inhibitor1962
nortriptyline1962
protriptyline1963
MAOI1965
maprotiline1970
mianserin1970
amoxapine1971
fluoxetine1975
paroxetine1977
Prozac1985
Seroxat1985
1970 Jrnl. Medicinal Chem. 13 36/1 Compound 5 (mianserin) proved to have..a less pronounced sedative effect and a lower acute toxicity as shown in pilot experiments on animals.
1986 C. W. Thornber in C. A. Heaton Chem. Industry iv. 189 Further chemical modifications have led to variants such as mianserin..which has additional properties as a serotonin antagonist.
1989 New Scientist 18 Mar. 31/2 The Committee on Safety of Medicines..declared that doctors' reports of adverse reactions in the blood to the antidepressant drug mianserin (Bolvidon) confirmed its own earlier warnings that the elderly are abnormally susceptible to these reactions.
1998 European Neuropsychopharmacol. 8 297 The antinociceptive effects of the tetracyclic antidepressant mianserin and its interaction with various opioid receptor subtypes was evaluated.
This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).
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n.1970
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