MHCn.

Brit.

/ˌɛmeɪtʃˈsiː/, U.S.

/ˌɛmˌeɪtʃˈsi/

Origin: Formed within English, as an initialism. Etymon: major histocompatibility complex n. at major adj. and n.¹ Compounds.

Etymology: Initialism < major histocompatibility complex n. at major adj. and n.¹ Compounds.

Immunology.

= major histocompatibility complex n. at major adj. and n.¹ Compounds. Frequently attributive.

ΚΠ

1972 Jrnl. Exper. Med. 136 1430 In a few cases we have studied animals differing for the MHC and for loci segregating independently of the MHC.

1984 M. J. Taussig Processes in Pathol. & Microbiol. (ed. 2) ii. 170 The small chain, called β-microglobulin, is not coded in the MHC and is common to all class I molecules.

1997 Esquire Dec. 140/3 Research has shown that female animals are most attracted to males whose major histocompatibility complex (MHC)—a group of genes responsible for detecting disease in the immune system—is least like their own.

2000 Jrnl. Neuroimmunol. 107 191 Gene mapping of F2 crosses between susceptible and resistant rat strains demonstrated nine genome regions outside the MHC which regulate different phenotypes of rat EAE [= experimental autoimmune encephalomyelitis].

Compounds

C1. General attributive, as MHC allele, MHC chromosome, etc.

ΚΠ

1972 Jrnl. Exper. Med. 136 1434 In this particular experiment cells of four mouse strains that carry nonrecombinant MHC chromosomes are tested in all possible combinations.

1989 B. Alberts et al. Molecular Biol. Cell (ed. 2) xviii. 1040 It is very rare for two individuals to have an identical set of MHC glycoproteins.

1994 J. Michael Tangled Web ii. xi. 166 How much of the variation in individuals is determined by the ability of the MHC protein to bind different antigens.

2000 New Scientist 19 Aug. 38/2 Nearly every victim of Hirata's disease..carries the MHC allele known as DR4w13.

C2.

MHC molecule n. any of the cell-surface glycoproteins that are encoded by genes of the major histocompatibility complex and that are involved in the regulation of immune responses.

ΚΠ

1979 Enzyme Defects & Immune Dysfunction: Ciba Found. Symp. 1978 19 The course of B and T lymphocyte differentiation is largely the same except for a final processing of T lymphocytes in the thymus; the processing is directed by MHC molecules of the thymus epithelium.

1993 Cell 73 207/1 CD4 and CD8 molecules..function as coreceptors binding to nonpolymorphic portions of class II and class I MHC molecules, respectively..: cross-linking of either a CD4 or CD8 coreceptor with the αβTCR by the same MHC molecule is required for efficient activation of T cells.

MHC-restricted adj. subject to MHC restriction.

ΚΠ

1978 Jrnl. Immunol. 121 274 We investigated the mechanism(s) by which MHC-restricted suppressor T cells..suppress the DNFB contact sensitivity response.

1997 In Vivo 11 351 DCs [sc. thymic stromal dendritic cells] initiate several immune responses, such as the sensitization of MHC-restricted T lymphocytes, resistance to infections and neoplasms, rejection of organ transplants, and the formation of T-dependent antibodies.

MHC restriction n. the phenomenon by which T-lymphocytes can recognize foreign antigens only when these are presented in association with self MHC molecules.

ΚΠ

1979 Immunology 38 835 (title) MHC restriction of murine T lymphocyte reactivity analysed by growth of bone marrow cells in vitro on thymus epithelial monolayers.

1996 Cellular Immunol. 169 174 A temperature-sensitive line of thymic nurse cells..was used in long-term coincubation experiments to determine nurse cell function during the process of MHC restriction.

This is a new entry (OED Third Edition, December 2001; most recently modified version published online March 2022).

单词	mhc
释义	MHCn. Brit. /ˌɛmeɪtʃˈsiː/, U.S. /ˌɛmˌeɪtʃˈsi/ Origin: Formed within English, as an initialism. Etymon: major histocompatibility complex n. at major adj. and n.¹ Compounds. Etymology: Initialism < major histocompatibility complex n. at major adj. and n.¹ Compounds. Immunology. = major histocompatibility complex n. at major adj. and n.¹ Compounds. Frequently attributive. ΚΠ 1972 Jrnl. Exper. Med. 136 1430 In a few cases we have studied animals differing for the MHC and for loci segregating independently of the MHC. 1984 M. J. Taussig Processes in Pathol. & Microbiol. (ed. 2) ii. 170 The small chain, called β-microglobulin, is not coded in the MHC and is common to all class I molecules. 1997 Esquire Dec. 140/3 Research has shown that female animals are most attracted to males whose major histocompatibility complex (MHC)—a group of genes responsible for detecting disease in the immune system—is least like their own. 2000 Jrnl. Neuroimmunol. 107 191 Gene mapping of F2 crosses between susceptible and resistant rat strains demonstrated nine genome regions outside the MHC which regulate different phenotypes of rat EAE [= experimental autoimmune encephalomyelitis]. Compounds C1. General attributive, as MHC allele, MHC chromosome, etc. ΚΠ 1972 Jrnl. Exper. Med. 136 1434 In this particular experiment cells of four mouse strains that carry nonrecombinant MHC chromosomes are tested in all possible combinations. 1989 B. Alberts et al. Molecular Biol. Cell (ed. 2) xviii. 1040 It is very rare for two individuals to have an identical set of MHC glycoproteins. 1994 J. Michael Tangled Web ii. xi. 166 How much of the variation in individuals is determined by the ability of the MHC protein to bind different antigens. 2000 New Scientist 19 Aug. 38/2 Nearly every victim of Hirata's disease..carries the MHC allele known as DR4w13. C2. MHC molecule n. any of the cell-surface glycoproteins that are encoded by genes of the major histocompatibility complex and that are involved in the regulation of immune responses. ΚΠ 1979 Enzyme Defects & Immune Dysfunction: Ciba Found. Symp. 1978 19 The course of B and T lymphocyte differentiation is largely the same except for a final processing of T lymphocytes in the thymus; the processing is directed by MHC molecules of the thymus epithelium. 1993 Cell 73 207/1 CD4 and CD8 molecules..function as coreceptors binding to nonpolymorphic portions of class II and class I MHC molecules, respectively..: cross-linking of either a CD4 or CD8 coreceptor with the αβTCR by the same MHC molecule is required for efficient activation of T cells. MHC-restricted adj. subject to MHC restriction. ΚΠ 1978 Jrnl. Immunol. 121 274 We investigated the mechanism(s) by which MHC-restricted suppressor T cells..suppress the DNFB contact sensitivity response. 1997 In Vivo 11 351 DCs [sc. thymic stromal dendritic cells] initiate several immune responses, such as the sensitization of MHC-restricted T lymphocytes, resistance to infections and neoplasms, rejection of organ transplants, and the formation of T-dependent antibodies. MHC restriction n. the phenomenon by which T-lymphocytes can recognize foreign antigens only when these are presented in association with self MHC molecules. ΚΠ 1979 Immunology 38 835 (title) MHC restriction of murine T lymphocyte reactivity analysed by growth of bone marrow cells in vitro on thymus epithelial monolayers. 1996 Cellular Immunol. 169 174 A temperature-sensitive line of thymic nurse cells..was used in long-term coincubation experiments to determine nurse cell function during the process of MHC restriction. This is a new entry (OED Third Edition, December 2001; most recently modified version published online March 2022). < n.1972
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