mercaptopurinen.

Brit.

/məːˌkaptə(ʊ)ˈp(j)ʊəriːn/,

/məːˌkaptə(ʊ)ˈpjɔːriːn/, U.S.

/mərˈˌkæptoʊˈpjʊˌrin/,

/mərˌkæptoʊˈpjʊr(ə)n/; see also mercapto- comb. form.

Origin: Formed within English, by compounding. Etymons: mercapto- comb. form, purine n.

Etymology: < mercapto- comb. form + purine n.

Chiefly Medicine.

Any of various thiol derivatives of purine; spec. 6-mercaptopurine, C₅H₄N₄S, an antineoplastic agent given orally in the treatment of leukaemia.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for cancer or leukemia

amethopterin1948

Myleran1952

Laetrile1953

thioguanine1953

thioTEPA1953

mercaptopurine1954

methotrexate1955

busulfan1956

chlorambucil1956

cyclophosphamide1960

vinblastine1962

vincristine1962

levamisole1969

vinca alkaloid1970

doxorubicin1971

tamoxifen1972

Airol1974

trastuzumab1997

thiotepa-

1954 Amer. Jrnl. Med. Sci. 228 376/2 We have in mercaptopurine a new type of agent which has demonstrated activity against experimental tumors and leukemias in the mouse and against leukemia in man.

1961 Lancet 7 Oct. 821/1 Methotrexate..and mercaptopurine..are folic-acid antagonists, which..interfere with nucleic-acid synthesis by inhibiting folic-acid reductase.

1973 Arthritis & Rheumatism 16 139 Thirteen patients with psoriasis and arthritis were treated with 6-mercaptopurine in dosages ranging from 20 to 150 mg/day.

1992 C. A. Smith & E. J. Wood Biosynthesis vii. 144 A modified form of 6-mercaptopurine, azathioprine, is an important immunosuppressive drug for use in tissue transplantation.

This entry has been updated (OED Third Edition, September 2001; most recently modified version published online March 2022).

单词	mercaptopurine
释义	mercaptopurinen. Brit. /məːˌkaptə(ʊ)ˈp(j)ʊəriːn/, /məːˌkaptə(ʊ)ˈpjɔːriːn/, U.S. /mərˈˌkæptoʊˈpjʊˌrin/, /mərˌkæptoʊˈpjʊr(ə)n/; see also mercapto- comb. form. Origin: Formed within English, by compounding. Etymons: mercapto- comb. form, purine n. Etymology: < mercapto- comb. form + purine n. Chiefly Medicine. Any of various thiol derivatives of purine; spec. 6-mercaptopurine, C₅H₄N₄S, an antineoplastic agent given orally in the treatment of leukaemia. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for cancer or leukemia amethopterin1948 Myleran1952 Laetrile1953 thioguanine1953 thioTEPA1953 mercaptopurine1954 methotrexate1955 busulfan1956 chlorambucil1956 cyclophosphamide1960 vinblastine1962 vincristine1962 levamisole1969 vinca alkaloid1970 doxorubicin1971 tamoxifen1972 Airol1974 trastuzumab1997 thiotepa- 1954 Amer. Jrnl. Med. Sci. 228 376/2 We have in mercaptopurine a new type of agent which has demonstrated activity against experimental tumors and leukemias in the mouse and against leukemia in man. 1961 Lancet 7 Oct. 821/1 Methotrexate..and mercaptopurine..are folic-acid antagonists, which..interfere with nucleic-acid synthesis by inhibiting folic-acid reductase. 1973 Arthritis & Rheumatism 16 139 Thirteen patients with psoriasis and arthritis were treated with 6-mercaptopurine in dosages ranging from 20 to 150 mg/day. 1992 C. A. Smith & E. J. Wood Biosynthesis vii. 144 A modified form of 6-mercaptopurine, azathioprine, is an important immunosuppressive drug for use in tissue transplantation. This entry has been updated (OED Third Edition, September 2001; most recently modified version published online March 2022). < n.1954
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