mercaptopurinen.
/məːˌkaptə(ʊ)ˈp(j)ʊəriːn/, /məːˌkaptə(ʊ)ˈpjɔːriːn/, U.S. /mərˈˌkæptoʊˈpjʊˌrin/, /mərˌkæptoʊˈpjʊr(ə)n/; see also mercapto- comb. form. Chiefly Medicine.
Any of various thiol derivatives of purine; spec. 6-mercaptopurine, C5H4N4S, an antineoplastic agent given orally in the treatment of leukaemia.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for cancer or leukemia
amethopterin1948
Myleran1952
Laetrile1953
thioguanine1953
thioTEPA1953
mercaptopurine1954
methotrexate1955
busulfan1956
chlorambucil1956
cyclophosphamide1960
vinblastine1962
vincristine1962
levamisole1969
vinca alkaloid1970
doxorubicin1971
tamoxifen1972
Airol1974
trastuzumab1997
thiotepa-
1954 Amer. Jrnl. Med. Sci. 228 376/2 We have in mercaptopurine a new type of agent which has demonstrated activity against experimental tumors and leukemias in the mouse and against leukemia in man.
1961 Lancet 7 Oct. 821/1 Methotrexate..and mercaptopurine..are folic-acid antagonists, which..interfere with nucleic-acid synthesis by inhibiting folic-acid reductase.
1973 Arthritis & Rheumatism 16 139 Thirteen patients with psoriasis and arthritis were treated with 6-mercaptopurine in dosages ranging from 20 to 150 mg/day.
1992 C. A. Smith & E. J. Wood Biosynthesis vii. 144 A modified form of 6-mercaptopurine, azathioprine, is an important immunosuppressive drug for use in tissue transplantation.
This entry has been updated (OED Third Edition, September 2001; most recently modified version published online March 2022).
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n.1954