单词 | methsuximide |
释义 | methsuximiden. Pharmacology. An anticonvulsant drug similar to but somewhat more toxic than ethosuximide, used chiefly for the treatment of refractory absence and myoclonic seizures; N,2-dimethyl-2-phenylsuccinimide, C12H13NO2.International Nonproprietary Name (1996): mesuximide. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > sedatives, antispasmodics, etc. > [noun] > antispasmodic or anticonvulsant > specific substances or preparations Dilantin1938 phenytoin1942 Artane1948 Mysoline1949 mephenesin1952 troxidone1952 primidone1953 acetazolamide1954 orphenadrine1957 tetrabenazine1958 ethosuximide1960 methsuximide1965 clonazepam1970 valproic1972 valproate1974 1965 National Formulary (Amer. Pharm. Assoc.) (ed. 12) 258/1 Methsuximide..contains not less than 97 per cent and not more than 103 per cent of C12H13NO2 calculated on the dried basis. 1967 Martindale's Extra Pharmacopoeia (ed. 25) 1082/1 In about one-third of the patients given methsuximide, minor side-effects occur which include anorexia, nausea, vomiting, constipation..and ataxia. 1972 R. White Be not Afraid xvi. 190 Celontin (or methsuximide) is billed as an anticonvulsant. 1996 Seizure 5 47 Methsuximide monotherapy as demonstrated in these five patients is an effective treatment for JME [= juvenile myoclonic epilepsy]. This is a new entry (OED Third Edition, December 2001; most recently modified version published online March 2022). < |
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