methisazonen.
/mᵻˈθʌɪsəˌzəʊn/, U.S. /məˈθaɪsəˌzoʊn/ Pharmacology.
A thiosemicarbazone that inhibits viral protein production, once used for the prophylaxis of smallpox and the treatment of vaccination complications; N-methylisatin 3-thiosemicarbazone, C10H10N4OS.International Nonproprietary Name (1996) and British Approved Name (1998): metisazone.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for smallpox
methisazone1964
1964 Brit. Med. Jrnl. 5 Sept. 621/1 Methisazone breaks new ground in the rational therapy of virus infections.
1966 New Scientist 17 Nov. 336/3 Dr D. J. Bauer and Dr K. Apostolov..had shown methisazone (‘Marboran’) to be active against certain adenoviruses growing in tissue culture.
1970 R. Passmore & J. S. Robson Compan. Med. Stud. II. xx. 36/1 In man, methisazone has been shown to be effective in preventing disease in contacts of patients suffering from smallpox... Methisazone has not been shown to be effective in treating established infections.
1978 Nature 13 Apr. 583/1 The search for effective antiviral agents... The clinically useful compounds are 1-methylisatin 3-thiosemicarbazone (methisazone), [etc.].
1988 Antiviral Res. 9 379 Metisazone and bis-benzimidazole were also effective against IHNV [= infectious hematopoietic necrosis virus].
1996 Drugs under Exper. & Clin. Res. 22 213 The preparation Ukrain was studied..in comparison with amitozin as its structural and functional analogue, and two other functional analogues, namely methisazone (against herpesvirus and poxvirus) and remantadine.
This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).
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n.1964