methicillinn.

Brit.

/ˌmɛθᵻˈsɪlɪn/, U.S.

/ˌmɛθəˈsɪlᵻn/

Origin: Formed within English, by compounding. Etymons: methoxy- comb. form, penicillin n.

Etymology: < meth- (in methoxy- comb. form) + -icillin (in penicillin n.).

Pharmacology.

A semi-synthetic penicillin that is resistant to the action of staphylococcal penicillinase; 6-(2,6-dimethoxybenzamido) penicillanic acid sodium, C₁₇H₁₉N₂O₆NaS·H₂O. More fully methicillin sodium, sodium methicillin.Methicillin was first marketed under the name celbenin.International Nonproprietary Name (1996): meticillin.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > antibiotics > [noun] > penicillin > other penicillin antibiotics

citrinin1931

griseofulvin1939

patulin1943

procaine penicillin1949

celbenin1960

methicillin1961

amoxicillin1971

1961 Lancet 4 Mar. 473/2 More recently another form of penicillin has been developed..which has now been given the B.P. approved name of sodium methicillin.

1961 Brit. Med. Jrnl. 25 Mar. 865/1 During a period of 12 weeks one ward was sprayed at regular intervals daily with 4g. of methicillin.

1967 Canad. Med. Assoc. Jrnl. 97 128/2 The semisynthetic penicillins such as sodium methicillin, [etc.]..are equally dangerous when penicillin hypersensitivity is suspected.

1970 Daily Tel. 23 Oct. 13/3 The second [semi-synthetic penicillin], methicillin,..was active against the resistant staphylococci and was soon accepted as a major life-saving antibiotic.

1988 Q. N. Myrvik & R. S. Weiser Fund. Med. Bacteriol. & Mycol. (ed. 2) vi. 90 The principal classes of semisynthetic penicillins include: the antistaphylococcal penicillins (methicillin, oxacillin, nafcillin)..whose major advantage is resistance to the action of penicillinases.

Compounds

methicillin-resistant adj. designating staphylococci and other bacteria that are resistant to methicillin; cf. MRSA n. at M n. Initialisms 1.

ΚΠ

1961 Jrnl. Clin. Pathol. 14 385 (title) Methicillin-resistant staphylococci.

1972 Appl. Microbiol. 24 240 (title) Reliability of the Kirby-Bauer disc diffusion method for detecting methicillin-resistant strains of Staphylococcus aureus.

1985 Drug Intelligence & Clin. Pharmacy 19 895 Only methicillin-resistant organisms, Strep. faecium, Pseudomonas cepacia, and Pseudomonas maltophilia have been shown to be resistant [to imipenem].

2000 Marie Claire July 264/2 MRSA (methicillin-resistant staphylococcus aureus—also known as ‘staph’) is a bacterium carried in the nose of twenty to 40 per cent of healthy people.

This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).

单词	methicillin
释义	methicillinn. Brit. /ˌmɛθᵻˈsɪlɪn/, U.S. /ˌmɛθəˈsɪlᵻn/ Origin: Formed within English, by compounding. Etymons: methoxy- comb. form, penicillin n. Etymology: < meth- (in methoxy- comb. form) + -icillin (in penicillin n.). Pharmacology. A semi-synthetic penicillin that is resistant to the action of staphylococcal penicillinase; 6-(2,6-dimethoxybenzamido) penicillanic acid sodium, C₁₇H₁₉N₂O₆NaS·H₂O. More fully methicillin sodium, sodium methicillin.Methicillin was first marketed under the name celbenin.International Nonproprietary Name (1996): meticillin. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > antibiotics > [noun] > penicillin > other penicillin antibiotics citrinin1931 griseofulvin1939 patulin1943 procaine penicillin1949 celbenin1960 methicillin1961 amoxicillin1971 1961 Lancet 4 Mar. 473/2 More recently another form of penicillin has been developed..which has now been given the B.P. approved name of sodium methicillin. 1961 Brit. Med. Jrnl. 25 Mar. 865/1 During a period of 12 weeks one ward was sprayed at regular intervals daily with 4g. of methicillin. 1967 Canad. Med. Assoc. Jrnl. 97 128/2 The semisynthetic penicillins such as sodium methicillin, [etc.]..are equally dangerous when penicillin hypersensitivity is suspected. 1970 Daily Tel. 23 Oct. 13/3 The second [semi-synthetic penicillin], methicillin,..was active against the resistant staphylococci and was soon accepted as a major life-saving antibiotic. 1988 Q. N. Myrvik & R. S. Weiser Fund. Med. Bacteriol. & Mycol. (ed. 2) vi. 90 The principal classes of semisynthetic penicillins include: the antistaphylococcal penicillins (methicillin, oxacillin, nafcillin)..whose major advantage is resistance to the action of penicillinases. Compounds methicillin-resistant adj. designating staphylococci and other bacteria that are resistant to methicillin; cf. MRSA n. at M n. Initialisms 1. ΚΠ 1961 Jrnl. Clin. Pathol. 14 385 (title) Methicillin-resistant staphylococci. 1972 Appl. Microbiol. 24 240 (title) Reliability of the Kirby-Bauer disc diffusion method for detecting methicillin-resistant strains of Staphylococcus aureus. 1985 Drug Intelligence & Clin. Pharmacy 19 895 Only methicillin-resistant organisms, Strep. faecium, Pseudomonas cepacia, and Pseudomonas maltophilia have been shown to be resistant [to imipenem]. 2000 Marie Claire July 264/2 MRSA (methicillin-resistant staphylococcus aureus—also known as ‘staph’) is a bacterium carried in the nose of twenty to 40 per cent of healthy people. This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022). < n.1961
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