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metalloproteinase
metalloproteinase n. 
/ˌmɛtl̩ə(ʊ)ˈprəʊtᵻneɪz/, /mᵻˌtalə(ʊ)ˈprəʊtᵻneɪz/, /ˌmɛtələ(ʊ)ˈprəʊtᵻneɪs/, /ˌmɛtl̩ə(ʊ)ˈprəʊtᵻneɪs/, /mᵻˌtalə(ʊ)ˈprəʊtᵻneɪs/, /məˌtæloʊˈproʊd(i)əˌneɪz/, /ˌmɛdl̩oʊˈproʊd(i)əˌneɪs/, /məˌtæloʊˈproʊd(i)əˌneɪs/ Biochemistry any of a group of proteolytic enzymes containing a metal ion that is an essential part of the catalytic mechanism; esp. (more fully matrix metalloproteinase) any of several groups of such enzymes that degrade proteins of the extracellular matrix, such as collagen.
Brit. /ˌmɛtələ(ʊ)ˈprəʊtᵻneɪz/
, /ˌmɛtələ(ʊ)ˈprəʊtᵻneɪz//ˌmɛtl̩ə(ʊ)ˈprəʊtᵻneɪz//mᵻˌtalə(ʊ)ˈprəʊtᵻneɪz//ˌmɛtələ(ʊ)ˈprəʊtᵻneɪs//ˌmɛtl̩ə(ʊ)ˈprəʊtᵻneɪs//mᵻˌtalə(ʊ)ˈprəʊtᵻneɪs/U.S. /ˌmɛdl̩oʊˈproʊd(i)əˌneɪz/
, /ˌmɛdl̩oʊˈproʊd(i)əˌneɪz//məˌtæloʊˈproʊd(i)əˌneɪz//ˌmɛdl̩oʊˈproʊd(i)əˌneɪs//məˌtæloʊˈproʊd(i)əˌneɪs/ΚΠ
1965 L. Cunningham in M. Florkin & E. H. Stotz Comprehensive Biochem. XVI. iii. 152 The range of types of metallo-proteinases appears to be very broad, and..little is known of most of them.
1991 New Scientist 8 June 40/1 These enzymes are known as matrix metalloproteinases or MMPs, and between them they can break down all the components of the collagen matrix.
1994 Diabetes Forecast May 54/1 Acott's project seeks to understand what triggers the development of these new blood vessels and the possible inhibiting effect of metalloproteinases on this process.
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