methapyrilenen.
/mɛθəˈpɪrᵻliːn/, U.S. /mɛθəˈpɪrəˌlin/ Pharmacology.
A pyridine derivative once used as an antihistamine and hypnotic, but later recognized to be a potent hepatic carcinogen in rats; N,N-dimethyl-N'-(2-thienylmethyl)-1,2-ethanediamine, C14H19N3S.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > antihistamine medicines > [adjective]
antihistamine1933
methapyrilene1949
the world > health and disease > healing > medicines or physic > medicines for specific purpose > sedatives, antispasmodics, etc. > [adjective] > sedative, narcotic, or hypnotic > specific drug
methapyrilene1949
the world > health and disease > healing > medicines or physic > medicines for specific purpose > antihistamine medicines > [noun]
pyribenzamine1946
diphenhydramine1947
tripelennamine1947
mepyramine1949
anti-histaminic1950
meclozine1955
triprolidine1956
antihistamine1957
trimeprazine1959
methapyrilene1974
the world > health and disease > healing > medicines or physic > medicines for specific purpose > sedatives, antispasmodics, etc. > [noun] > hypnotic > specific drugs
codeine1833
codeia1834
chloral1838
paraldehyde1857
hypnone1886
chloralamide1889
sulphonal1889
uralium1889
ural1891
thymacetin1892
chloralose1893
chloretone1899
hedonal1900
veronal1903
Medinal1908
barbitone1914
barbital1919
Sedormid1928
benzodiazepine1934
hexobarbital1941
hexobarbitone1941
glutethimide1955
Placidyl1955
Mogadon1956
chlordiazepoxide1960
nitrazepam1965
flurazepam1968
medazepam1968
lorazepam1969
Rohypnol1971
flunitrazepam1973
triazolam1973
methapyrilene1974
Halcion1975
1949 Jrnl. Amer. Med. Assoc. 23 July 1023/2 The fatal poisoning of a healthy girl 16 months of age was caused by the accidental ingestion of 100 mg. of methapyrilene hydrochloride.
1965 Appl. Therapeutics 7 832/2 Double blind studies in asthmatic children revealed that an antihistamine drug, methapyrilene hydrochloride, enhanced the effect of the bronchodilator drug.
1974 M. C. Gerald Pharmacol. ii. 20 Nonprescription..sleep-facilitating products,..have capitalized on the drowsiness induced by methapyrilene.
1977 Food & Cosmetics Toxicol. 15 269 Methapyrilene plus nitrite induced liver tumours in 30% [of treated rats].
1979 Tucson (Arizona) Citizen 20 Sept. 2 e/1 HEW officials felt that a recall of these products which contain methapyrilene would be ‘an appropriate action’.
1995 Toxicol. & Appl. Pharmacol. 131 216 Methapyrilene (MPH) was a widely used antihistamine until it was found to produce hepatocellular carcinoma and cholangiocarcinoma in Fischer 344 rats.
This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).
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n.1949