α. 1900s– McCune–Albright syndrome.
β. 1900s– McCune–Albright's syndrome (rare).
McCune–Albright syndromen.
/məˈkjuːn ˈɔːlbrʌɪt ˈsɪndrəʊm/, U.S. /məˈkjun ˈɔlˌbraɪt ˌsɪnˌdroʊm/, /məˈkjun ˈɑlˌbraɪt ˌsɪnˌdroʊm/ Medicine.
A disorder characterized by fibrous dysplasia of bones, patchy brown pigmentation of the skin, and endocrine dysfunction, esp. causing precocious puberty in girls. Also (and earlier) called Albright's syndrome.Cases of the syndrome were described independently by McCune in 1936 ( Amer. Jrnl. Dis. Children 52 743) and by Albright in 1937 (see Albright n. 1).
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the world > health and disease > ill health > a disease > diseases of tissue > disorders of bones > [noun] > other bone disorders
osteocachexy1857
osteitis deformans1877
Paget's disease1889
megalacria1891
osteochondritis dissecans1895
osteogenesis imperfecta1899
von Recklinghausen's disease1910
Albright's syndrome1940
fibrogenesis imperfecta ossium1952
pycnodysostosis1963
McCune–Albright syndrome1966
1966 Amer. Jrnl. Dis. Children 111 647/2 Sexual precocity, which forms part of the McCune-Albright syndrome in girls, is rarely noted in boys.
1968 Jrnl. Pediatrics 73 89 The syndrome is now known as McCune-Albright's syndrome or Albright's syndrome.
1993 Pediatric Radiol. 23 15/1 McCune-Albright syndrome is characterized by the triad of polyostotic fibrous dysplasia..,skin hyperpigmentation, and precocious puberty.
1998 Anticancer Res. 18 4415 Mutations that inhibit the GTPase activity of the a subunit of the stimulating G protein (Gsa) have been demonstrated in the myocardium of patients with McCune–Albright syndrome.
This entry has been updated (OED Third Edition, March 2001; most recently modified version published online March 2022).
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n.1966