meclozinen.

Brit.

/ˈmɛkləziːn/, U.S.

/ˈmɛkləˌzin/

Forms: 1900s– meclizine, 1900s– meclozine; U.S. 1900s– meclizine.

Origin: Apparently formed within English, by compounding. Etymons: methyl n., cyclizine n.

Etymology: Apparently earliest as meclizine < me- (in methyl n.) + -clizine (in cyclizine n.). In form meclozine perhaps remodelled after hydrochloride n. (see quot. 1957).

Pharmacology.

A piperazine derivative, C₂₅H₂₇ClN₂, with antihistamine properties, used mainly as an anti-emetic, esp. in preventing motion sickness.Meclozine is the International Nonproprietary Name and British Approved Name; meclizine is the name in the Pharmacopeia of the U.S.A.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > antihistamine medicines > [noun]

pyribenzamine1946

diphenhydramine1947

tripelennamine1947

mepyramine1949

anti-histaminic1950

meclozine1955

triprolidine1956

antihistamine1957

trimeprazine1959

methapyrilene1974

the world > health and disease > healing > medicines or physic > medicines for specific purpose > astringent or restringent preparations > [noun] > for stopping vomiting or nausea > specific drugs

Phenergan1948

Dramamine1949

promethazine1949

chlorpromazine1952

Marezine1952

Marzine1954

Thorazine1954

meclozine1955

perphenazine1957

trifluoperazine1958

metoclopramide1964

sulpiride1970

1955 Jrnl. Pharmacol. & Exper. Therapeutics 115 483 From a perceptual-motor viewpoint there would seem to be no valid reason why operating personnel could not take advantage of the beneficial effects which cyclizine, meclizine and promethazine have upon motion sickness.

1957 Brit. Pharmaceut. Codex 1954 Suppl. 39 Meclozine hydrochloride has the properties of the anti-histamine drugs.

1965 New Scientist 4 Nov. 328/2 Anti-histamines, containing meclizine, cyclizine and chlorcyclizine must now carry a strong warning label.

1995 Holiday Which? Mar. 111/5 Hyoscine (1) is the most effective medicine, but has potentially more unwanted side effects; cinnarizine (2), dimenhydrinate (3), meclozine (4), promethazine (5) or cyclizine (6) have fewer side effects.

This entry has been updated (OED Third Edition, June 2001; most recently modified version published online March 2022).

单词	meclozine
释义	meclozinen. Brit. /ˈmɛkləziːn/, U.S. /ˈmɛkləˌzin/ Forms: 1900s– meclizine, 1900s– meclozine; U.S. 1900s– meclizine. Origin: Apparently formed within English, by compounding. Etymons: methyl n., cyclizine n. Etymology: Apparently earliest as meclizine < me- (in methyl n.) + -clizine (in cyclizine n.). In form meclozine perhaps remodelled after hydrochloride n. (see quot. 1957). Pharmacology. A piperazine derivative, C₂₅H₂₇ClN₂, with antihistamine properties, used mainly as an anti-emetic, esp. in preventing motion sickness.Meclozine is the International Nonproprietary Name and British Approved Name; meclizine is the name in the Pharmacopeia of the U.S.A. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > antihistamine medicines > [noun] pyribenzamine1946 diphenhydramine1947 tripelennamine1947 mepyramine1949 anti-histaminic1950 meclozine1955 triprolidine1956 antihistamine1957 trimeprazine1959 methapyrilene1974 the world > health and disease > healing > medicines or physic > medicines for specific purpose > astringent or restringent preparations > [noun] > for stopping vomiting or nausea > specific drugs Phenergan1948 Dramamine1949 promethazine1949 chlorpromazine1952 Marezine1952 Marzine1954 Thorazine1954 meclozine1955 perphenazine1957 trifluoperazine1958 metoclopramide1964 sulpiride1970 1955 Jrnl. Pharmacol. & Exper. Therapeutics 115 483 From a perceptual-motor viewpoint there would seem to be no valid reason why operating personnel could not take advantage of the beneficial effects which cyclizine, meclizine and promethazine have upon motion sickness. 1957 Brit. Pharmaceut. Codex 1954 Suppl. 39 Meclozine hydrochloride has the properties of the anti-histamine drugs. 1965 New Scientist 4 Nov. 328/2 Anti-histamines, containing meclizine, cyclizine and chlorcyclizine must now carry a strong warning label. 1995 Holiday Which? Mar. 111/5 Hyoscine (1) is the most effective medicine, but has potentially more unwanted side effects; cinnarizine (2), dimenhydrinate (3), meclozine (4), promethazine (5) or cyclizine (6) have fewer side effects. This entry has been updated (OED Third Edition, June 2001; most recently modified version published online March 2022). < n.1955
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