maprotilinen.

Brit.

/məˈprəʊtᵻliːn/, U.S.

/məˈproʊdəˌlin/

Origin: Formed within English, by compounding. Etymon: amitriptyline n.

Etymology: < mapro-, of unknown origin + -tiline, alteration of -tyline (in amitriptyline n., protriptyline n., etc.).

Pharmacology.

A tetracyclic antidepressant with properties similar to those of tricyclic amitriptyline, usually administered orally as the hydrochloride; 3-(9,10-dihydro-9,10-ethanoanthracen-9-yl)propyl(methyl)amine, C₂₀H₂₃N.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > medicine for mental conditions > [noun] > antidepressant > specific drugs

Marsilid1952

iproniazid1953

levallorphan1953

imipramine1958

Tofranil1958

isocarboxazid1959

Marplan1959

Nardil1959

nialamide1959

Niamid1959

phenelzine1959

tranylcypromine1959

Parnate1960

amitriptyline1961

monoamine oxidase inhibitor1962

nortriptyline1962

protriptyline1963

MAOI1965

maprotiline1970

mianserin1970

amoxapine1971

fluoxetine1975

paroxetine1977

Prozac1985

Seroxat1985

1970 WHO Chron. 24 130 Maprotiline.

1976 Lancet 18 Dec. 1357/1 We have seen a patient with a rash and severe neutropenia probably associated with maprotiline hydrochloride (‘Ludiomil’), a tetracyclic antidepressant.

1983 D. Stafford-Clark & A. C. Smith Psychiatry for Students (ed. 6) vii. 118 Maprotiline (Ludiomil) has a different structure but it is not very different from nortriptyline in properties, dosage and side-effects.

1989 Jrnl. Psychopharmacol. 30 iv. 36 p Second generation atypical antidepressants produce a lesser incidence of poisoning fatalities than tricyclics and maprotiline.

1992 Internat. Clin. Psychopharmacol. 7 92/2 Active control therapy included amitriptyline, clomipramine, mianserin and maprotiline.

This entry has been updated (OED Third Edition, September 2000; most recently modified version published online March 2022).

单词	maprotiline
释义	maprotilinen. Brit. /məˈprəʊtᵻliːn/, U.S. /məˈproʊdəˌlin/ Origin: Formed within English, by compounding. Etymon: amitriptyline n. Etymology: < mapro-, of unknown origin + -tiline, alteration of -tyline (in amitriptyline n., protriptyline n., etc.). Pharmacology. A tetracyclic antidepressant with properties similar to those of tricyclic amitriptyline, usually administered orally as the hydrochloride; 3-(9,10-dihydro-9,10-ethanoanthracen-9-yl)propyl(methyl)amine, C₂₀H₂₃N. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > medicine for mental conditions > [noun] > antidepressant > specific drugs Marsilid1952 iproniazid1953 levallorphan1953 imipramine1958 Tofranil1958 isocarboxazid1959 Marplan1959 Nardil1959 nialamide1959 Niamid1959 phenelzine1959 tranylcypromine1959 Parnate1960 amitriptyline1961 monoamine oxidase inhibitor1962 nortriptyline1962 protriptyline1963 MAOI1965 maprotiline1970 mianserin1970 amoxapine1971 fluoxetine1975 paroxetine1977 Prozac1985 Seroxat1985 1970 WHO Chron. 24 130 Maprotiline. 1976 Lancet 18 Dec. 1357/1 We have seen a patient with a rash and severe neutropenia probably associated with maprotiline hydrochloride (‘Ludiomil’), a tetracyclic antidepressant. 1983 D. Stafford-Clark & A. C. Smith Psychiatry for Students (ed. 6) vii. 118 Maprotiline (Ludiomil) has a different structure but it is not very different from nortriptyline in properties, dosage and side-effects. 1989 Jrnl. Psychopharmacol. 30 iv. 36 p Second generation atypical antidepressants produce a lesser incidence of poisoning fatalities than tricyclics and maprotiline. 1992 Internat. Clin. Psychopharmacol. 7 92/2 Active control therapy included amitriptyline, clomipramine, mianserin and maprotiline. This entry has been updated (OED Third Edition, September 2000; most recently modified version published online March 2022). < n.1970
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