Marezinen.
/ˈmarəziːn/, U.S. /ˈmɛrəˌzin/ Pharmacology.
A piperazine derivative, cyclizine hydrochloride, given orally as an anti-emetic, esp. for the prevention and treatment of motion sickness; 1-diphenylmethyl-4-methylpiperazine monohydrochloride, C18H22N2.HCl. Cf. Marzine n.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > astringent or restringent preparations > [noun] > for stopping vomiting or nausea > specific drugs
Phenergan1948
Dramamine1949
promethazine1949
chlorpromazine1952
Marezine1952
Marzine1954
Thorazine1954
meclozine1955
perphenazine1957
trifluoperazine1958
metoclopramide1964
sulpiride1970
1952 Official Gaz. (U.S. Patent Office) 23 Dec. 1007/1 Marezine for medicinal preparations intended for use in the prevention or treatment of allergies, motion sickness, nausea and vomiting in pregnancy, or nausea due to other causes.
1954 Jrnl. Pharmacol. & Exper. Therapeutics 112 297 (heading) Pharmacologic properties of cyclizine hydrochloride (marezine).
1965 Economist 6 Nov. 615/2 The Food and Drug Administration announced last week that three anti-histamines—Bonine, Marezine and Cyclizine—which are used to combat nausea, including morning sickness, must carry a warning on their labels that, if taken by a pregnant woman, they may harm her unborn child.
1969 Guardian 21 July 9/2 Each [astronaut]..carries..45 milligrams of marezine for motion sickness.
1985 Aviation, Space, & Environmental Med. 56 310 Proficiency scores on the pursuit meter task were improved over placebo scores in subjects with d-amphetamine... Scores were not significantly different from placebo scores in tests with..marezine 50 mg.
This entry has been updated (OED Third Edition, December 2000; most recently modified version published online March 2022).
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n.1952