maculan.

a1400 tr. Lanfranc Sci. Cirurgie (Ashm.) (1894) 247 Macula is a wem in a mannys iȝe.

1820 R. Hooper Lexicon-medicum (ed. 4) 517/2 Maculæ albæ, white specks on the eye.

1844 W. Lawrence Treat. Dis. Eye (ed. 3) 358 The term macula is applied to small patches or specks [of corneal opacity].

1964 S. Duke-Elder Parsons' Dis. Eye (ed. 14) xvi. 191 If rather more dense it [sc. the corneal sac] is sometimes called a macula.

1984 Ophthalmologica 188 4/1 The results achieved in the group treated with Solcosenyl Eye-Gel were also more favourable with respect to the formation of a pronounced corneal macula after foreign body injury.

?a1425 tr. Guy de Chauliac Grande Chirurgie (N.Y. Acad. Med.) f. 125 (MED) To remoue maculas, i. spottes, & lentiginez, i. fraclez..Be þe fface anoynted with oile of tartre.

1722 J. Quincy Lexicon Physico-medicum (ed. 2) (at cited word) Macula, is applied by Physicians to express any Spots upon the Skin, whether those in Fevers, or scorbutick Habits.

1877 L. A. Duhring Pract. Treat. Dis. Skin 41 Maculæ are evanescent or permanent according to their cause.

1899 T. C. Allbutt et al. Syst. Med. VIII. 640 In all cases a deeply pigmented macula remains.

2001 Acta Dermato-venereologica 81 45/1 We report here a 62-year-old seemingly healthy patient who presented with disseminated erythematous maculae.

1670 Philos. Trans. (Royal Soc.) 5 1201 Next, the Macula, appearing somewhat prominent in one of the Arteries.

1860 G. Buchanan Kölliker's Man. Human Microsc. Anat. 560 The two granular layers, and the intermediate granular lamina, occur over the whole of the macula, the fovea centralis excepted.

1901 Philos. Trans. (Royal Soc.) B. 194 74 Fundus oculi (right eye) of the Lemurine Douroucouli. The macula is present, but the macula ring has disappeared.

1902 D. J. Cunningham Text-bk. Anat. 718 The structure of the maculæ in the utricle and saccule is practically the same.

1948 A. Brodal Neurol. Anat. vii. 213 The corresponding macula of the saccule has the same size, but its plane is vertical, perpendicular to that of the macula of the utricle. Both these maculae consist of hair-cells.

1952 Sci. News 23 73 When an object is fixed, the eyes are directed towards it in such a way that it is focused on the central spot of the retina—the area for acute vision, known as the macula.

1975 W. Barlow Alexander Princ. (new ed.) iii. 42 Posture in relation to gravity is continuously registered on the hairs of the maculae.

1992 N.Y. Times Mag. 17 May 46/1 The macula is the center of the retina that is responsible for visual detail.

1673 Gentlewomans Compan. 244 Some of late with an Optick-glass have discovered some maculæ or spots in the very face of the Sun.

1676 J. Glanvill Ess. iii. 19 The Moons libration, collected from the various position of its Maculæ.

1690 T. Burnet Theory of Earth iii. xi. 97 The Body of the Sun may contract..some Spots or Maculæ greater than usual.

1767 Ann. Reg. 1766 92/2 The spot or macula on the sun, mentioned to have appeared lately.

1861 G. F. Chambers Handbk. Descr. Astron. i. i. 4 The surface of the Sun's disc is frequently found covered with dark spots or maculae.

1983 P. Moore & G. Hunt Atlas Solar Syst. 296/1 The three named ‘macula’ objects [on Europa] (Thera Macula, Thrace Macula and Tyre Macula) can be identified without difficulty, but are not very striking.

1987 P. Moore Astron. Encycl. 151/2 The surface [of Europa] is icy, with virtually no craters..; new terms have had to be introduced to describe the surface features—..‘macula’ (a dark, sometimes irregular spot).

1802 J. Playfair Illustr. Huttonian Theory 298 Rectangular maculæ of feltspar.

1826 W. Kirby & W. Spence Introd. Entomol. IV. 285 Macula (Macula), a larger indeterminately shaped spot.

1913 N. K. Jardine Dict. Entomol. 91 Gutta, a roundish dot of colour, intermediate in size between an atom and a macula.

1942 Lancet 3 Oct. 394/2 Zimmerman [sic] first recognised the different appearance of the cells of the distal tubule most closely applied to the afferent arteriole in its juxtaglomerular portion. In this part, the ordinary tubular cells seem aggregated, and become in some species much higher and more columnar. Because of this grouping together of nuclei, and the impression of increased density of epithelial cells produced, Zimmerman called this the macula densa.

1952 A. C. Allen Kidney ii. 32/2 The macula densa in combination with the juxtaglomerular body is referred to as the juxtaglomerular apparatus.

1968 E. L. Becker Struct. Basis Renal Dis. i. 34 The juxtaglomerular apparatus..is considered to consist of four portions: the specialized portion of the afferent arteriole containing characteristic granules; the first portion of the distal convoluted tubule, or macula densa; the cushion of cells at the vascular pole, continuous with the mesangium..; and the efferent arteriole.

1985 C. R. Leeson et al. Textbk. Histol. (ed. 5) xiii. 421/1 The cells also are closely related to the macula densa, a specialised region of the distal convoluted tubule at its commencement.

1818 J. Wardrop Ess. Morbid Anat. Human Eye II. xli. 135 Besides the vascular and medullary lamina of the retina, there is a peculiar part of its structure called the Macula Lutea, discovered by Sömmerring... The macula lutea, which is observed near the centre of the retina, appears in the form of a spot of a yellow colour.

1967 G. M. Wyburn et al. Conc. Anat. viii. 206/2 In the centre of the retina is the yellow spot, the macula lutea.

1986 A. S. Romer & T. S. Parsons Vertebr. Body (ed. 6) xv. 514 The area centralis (sometimes termed macula lutea because, exceptionally, the area has a yellow tinge in man).