Mannichn.
/ˈmanɪk/, /ˈmanɪx/, U.S. /ˈmænɪk/ Chemistry.
attributive. Designating or relating to the condensation reaction between a primary or secondary amine (usually as the hydrochloride), an aldehyde, and a compound containing an active hydrogen atom, to form a β-amino ketone. Mannich base n. the product of such a reaction.
ΚΠ
1931 Jrnl. Chem. Soc. 3090 Keto-bases of the required type are readily obtained by the Mannich reaction.
1937 Jrnl. Chem. Soc. 54 In order to complete the chain of evidence for the constitution of the ketones..it seemed desirable to show that the ‘Mannich’ base from Z-methylcyclohexanone is of the form assumed.
1968 R. O. C. Norman Princ. Org. Synthesis viii. 273 The facts that the Mannich reaction is applicable to a wide range of compounds, is usually efficient, and gives products (Mannich bases) which undergo a number of types of transformation, give the process extensive applications in synthesis.
1985 A. Streitwieser & C. H. Heathcock Introd. Org. Chem. (ed. 3) xxiii. 722 Immonium ions are intermediates in an important reaction for formation of carbon-carbon bonds, the Mannich reaction.
This is a new entry (OED Third Edition, September 2000; most recently modified version published online March 2022).
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n.1931