lysergicadj.

Brit.

/lʌɪˈsəːdʒɪk/, U.S.

/laɪˈsərdʒɪk/

Etymology: < lys (in hydrolysis n.) + erg- (in ergot n.) + -ic suffix.

Chemistry.

lysergic acid:

a. A crystalline tetracyclic compound, C₁₆H₁₆N₂O₂, containing the indole nucleus and occurring in two enantiomorphic forms, the dextrorotatory one being produced by the hydrolysis of ergot alkaloids.

ΘΚΠ

the world > matter > chemistry > organic chemistry > organic compounds > [noun] > cyclic compounds > tricyclic compounds

xanthene1898

thioxanthene1911

psoralen1933

lysergic acid1934

cannabinoid1967

1934 Jacobs & Craig in Jrnl. Biol. Chem. 104 547 A new substance was obtained..which possessed both acid and basic properties and which we have named lysergic acid.

1961 New Scientist 2 Nov. 278 The alkaloids of ergot are all derivatives of lysergic acid, an indole compound.

1964 D. F. Downing in M. Gordon Psychopharmacol. Agents I. xiii. 572 Lysergic acid derivatives with biological activity are..known to occur both in fungi and higher plants. The most active hallucinogenic substance (LSD-25) has, however, been obtained only by synthesis from (+)-lysergic acid.

1969 T. A. Ban Psychopharmacol. xviii. 347/1 Lysergic acid diethylamide, or, as commonly referred to, LSD₂₅, is a synthetic product prepared from lysergic acid.

b. Used elliptically for lysergic acid diethylamide, or (less commonly) any derivative of the acid.

ΘΚΠ

the world > physical sensation > use of drugs and poison > an intoxicating drug > [noun] > hallucinogenic drug > LSD

white lightning1907

lysergic acid diethylamide1944

LSD1950

lysergic acid1952

acid1965

lysergide1965

purple haze1967

purple1968

Strawberry Fields1971

the world > matter > chemistry > organic chemistry > amides > [noun] > others

tartaric amide1789

cyanamide1838

sodamide1838

furfuramide1845

opiammone1845

formamide1852

param1866

tartranil1868

terephthalamide1868

sulphonamide1881

acrylamide1893

caprolactam1944

lysergic acid1952

thioTEPA1953

lipoamide1960

1952 Jrnl. Mental Sci. 98 314 High doses of glucose raising the blood sugar above 200 mgm. inhibit the action of lysergic acid (LSD. 25).

1954 Brit. Jrnl. Psychol. 45 274 The visions produced by such drugs as mescaline and lysergic acid.

1955 Sci. Amer. June 39/1 The creation of experimental psychoses with lysergic acid thus opens the way to studying treatments and the nature of mental illness.

1957 J. S. Huxley Relig. without Revelation vii. 168 Mescalin and lysergic acid induce remarkable intensifications and modifications of consciousness, including often a sense of transcendence of self.

1958 Sunday Times 1 June 7/5 Lysergic acid should be tried for its extraordinary property of resurrecting childhood.

1962 Observer 15 July 1/5 The American Medical Association has given a warning that use of the drug known as LSD-25, or lysergic acid, can lead to suicide, and that LSD-25 has joined the ranks of black-market drugs like marijuana and heroin.

1964 New Statesman 28 Feb. 347/3 (advt.) Author seeks objective confirmation of subjective mystical experience under Lysergic Acid (LSD 25).

1969 T. A. Ban Psychopharmacol. xviii. 348/1 Other lysergic acids. Besides LSD₂₅ there are at least eight other lysergic acid derivatives with psychotomimetic properties.

1972 Daily Tel. 11 Aug. (Colour Suppl.) 12/3 The acids, like the barbiturates and amphetamines, are synthetically produced, and the best known is lysergic acid, LSD.

Derivatives

lysergic acid diethylamide n. /daɪˈɛθɪl-//daɪəˈθaɪləmaɪd/ the diethylamide of lysergic acid (in which the group —N(C₂H₅)₂ replaces the hydroxyl group of the acid), an extremely powerful synthetic hallucinogen which can produce profound changes in perception (esp. vision) and mood, with psychotic symptoms resembling those of schizophrenia, and which has been given orally in psychotherapy, usually as the water-soluble tartrate, a colourless odourless powder; also called LSD², lysergide n.

ΘΚΠ

the world > physical sensation > use of drugs and poison > an intoxicating drug > [noun] > hallucinogenic drug > LSD

white lightning1907

lysergic acid diethylamide1944

LSD1950

lysergic acid1952

acid1965

lysergide1965

purple haze1967

purple1968

Strawberry Fields1971

1944 Chem. Abstr. 38 1502 With NHEt₂ condensation gave d-lysergic acid diethylamide.

1950 Diseases Nervous Syst. XI. 241/1 Occasionally, it was observed that patients were able to verbalize the repressed components of their conflicts during a toxic delirium. This led us to consider various drugs that might induce a transitory delirious state. It was during this search that the Sandoz Company called to our attention and made available d-lysergic acid diethylamide (L.S.D. 25).

1955 Sci. News Let. 2 July 4/1 LSD, short for lysergic acid diethylamide, is a chemical that produces hallucinations and delusions in healthy persons like those in mental sickness.

1965 New Scientist 22 Apr. 224/3 Lysergic acid diethylamide (LSD 25) and mescaline are..often called ‘psychotomimetic’, because some of the symptoms which they produce create certain resemblances to schizophrenic illness.

1967 Economist 7 Oct. 20/1 The coming thing is lysergic acid diethylamide (LSD).

1969 [see sense a].

1971 Nature 29 Jan. 347/1 Small doses (∼ 100 μg) of lysergic acid diethylamide (LSD) taken orally cause hallucinations and distortions of visual perception in man.

1971 Nature 16 July 191/1 Lysergic acid diethylamide (LSD-25) is believed to cause chromosome abnormalities.

This entry has not yet been fully updated (first published 1976; most recently modified version published online March 2022).

单词	lysergic
释义	lysergicadj. Brit. /lʌɪˈsəːdʒɪk/, U.S. /laɪˈsərdʒɪk/ Etymology: < lys (in hydrolysis n.) + erg- (in ergot n.) + -ic suffix. Chemistry. lysergic acid: a. A crystalline tetracyclic compound, C₁₆H₁₆N₂O₂, containing the indole nucleus and occurring in two enantiomorphic forms, the dextrorotatory one being produced by the hydrolysis of ergot alkaloids. ΘΚΠ the world > matter > chemistry > organic chemistry > organic compounds > [noun] > cyclic compounds > tricyclic compounds xanthene1898 thioxanthene1911 psoralen1933 lysergic acid1934 cannabinoid1967 1934 Jacobs & Craig in Jrnl. Biol. Chem. 104 547 A new substance was obtained..which possessed both acid and basic properties and which we have named lysergic acid. 1961 New Scientist 2 Nov. 278 The alkaloids of ergot are all derivatives of lysergic acid, an indole compound. 1964 D. F. Downing in M. Gordon Psychopharmacol. Agents I. xiii. 572 Lysergic acid derivatives with biological activity are..known to occur both in fungi and higher plants. The most active hallucinogenic substance (LSD-25) has, however, been obtained only by synthesis from (+)-lysergic acid. 1969 T. A. Ban Psychopharmacol. xviii. 347/1 Lysergic acid diethylamide, or, as commonly referred to, LSD₂₅, is a synthetic product prepared from lysergic acid. b. Used elliptically for lysergic acid diethylamide, or (less commonly) any derivative of the acid. ΘΚΠ the world > physical sensation > use of drugs and poison > an intoxicating drug > [noun] > hallucinogenic drug > LSD white lightning1907 lysergic acid diethylamide1944 LSD1950 lysergic acid1952 acid1965 lysergide1965 purple haze1967 purple1968 Strawberry Fields1971 the world > matter > chemistry > organic chemistry > amides > [noun] > others tartaric amide1789 cyanamide1838 sodamide1838 furfuramide1845 opiammone1845 formamide1852 param1866 tartranil1868 terephthalamide1868 sulphonamide1881 acrylamide1893 caprolactam1944 lysergic acid1952 thioTEPA1953 lipoamide1960 1952 Jrnl. Mental Sci. 98 314 High doses of glucose raising the blood sugar above 200 mgm. inhibit the action of lysergic acid (LSD. 25). 1954 Brit. Jrnl. Psychol. 45 274 The visions produced by such drugs as mescaline and lysergic acid. 1955 Sci. Amer. June 39/1 The creation of experimental psychoses with lysergic acid thus opens the way to studying treatments and the nature of mental illness. 1957 J. S. Huxley Relig. without Revelation vii. 168 Mescalin and lysergic acid induce remarkable intensifications and modifications of consciousness, including often a sense of transcendence of self. 1958 Sunday Times 1 June 7/5 Lysergic acid should be tried for its extraordinary property of resurrecting childhood. 1962 Observer 15 July 1/5 The American Medical Association has given a warning that use of the drug known as LSD-25, or lysergic acid, can lead to suicide, and that LSD-25 has joined the ranks of black-market drugs like marijuana and heroin. 1964 New Statesman 28 Feb. 347/3 (advt.) Author seeks objective confirmation of subjective mystical experience under Lysergic Acid (LSD 25). 1969 T. A. Ban Psychopharmacol. xviii. 348/1 Other lysergic acids. Besides LSD₂₅ there are at least eight other lysergic acid derivatives with psychotomimetic properties. 1972 Daily Tel. 11 Aug. (Colour Suppl.) 12/3 The acids, like the barbiturates and amphetamines, are synthetically produced, and the best known is lysergic acid, LSD. Derivatives lysergic acid diethylamide n. /daɪˈɛθɪl-//daɪəˈθaɪləmaɪd/ the diethylamide of lysergic acid (in which the group —N(C₂H₅)₂ replaces the hydroxyl group of the acid), an extremely powerful synthetic hallucinogen which can produce profound changes in perception (esp. vision) and mood, with psychotic symptoms resembling those of schizophrenia, and which has been given orally in psychotherapy, usually as the water-soluble tartrate, a colourless odourless powder; also called LSD², lysergide n. ΘΚΠ the world > physical sensation > use of drugs and poison > an intoxicating drug > [noun] > hallucinogenic drug > LSD white lightning1907 lysergic acid diethylamide1944 LSD1950 lysergic acid1952 acid1965 lysergide1965 purple haze1967 purple1968 Strawberry Fields1971 1944 Chem. Abstr. 38 1502 With NHEt₂ condensation gave d-lysergic acid diethylamide. 1950 Diseases Nervous Syst. XI. 241/1 Occasionally, it was observed that patients were able to verbalize the repressed components of their conflicts during a toxic delirium. This led us to consider various drugs that might induce a transitory delirious state. It was during this search that the Sandoz Company called to our attention and made available d-lysergic acid diethylamide (L.S.D. 25). 1955 Sci. News Let. 2 July 4/1 LSD, short for lysergic acid diethylamide, is a chemical that produces hallucinations and delusions in healthy persons like those in mental sickness. 1965 New Scientist 22 Apr. 224/3 Lysergic acid diethylamide (LSD 25) and mescaline are..often called ‘psychotomimetic’, because some of the symptoms which they produce create certain resemblances to schizophrenic illness. 1967 Economist 7 Oct. 20/1 The coming thing is lysergic acid diethylamide (LSD). 1969 [see sense a]. 1971 Nature 29 Jan. 347/1 Small doses (∼ 100 μg) of lysergic acid diethylamide (LSD) taken orally cause hallucinations and distortions of visual perception in man. 1971 Nature 16 July 191/1 Lysergic acid diethylamide (LSD-25) is believed to cause chromosome abnormalities. This entry has not yet been fully updated (first published 1976; most recently modified version published online March 2022). < adj.1934
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