单词 | long-term potentiation |
释义 | > as lemmaslong-term potentiation long-term potentiation n. Physiology long-lasting facilitation of neurotransmission at a synapse following natural or artificial stimulation of the synapse under specific conditions, which is believed to be a cellular mechanism of plasticity in the brain and to be involved especially in learning and memory; abbreviated LTP. ΚΠ 1969 R. Llinás & C. Nicholson in Neurobiol. Cerebellar Evol. & Devel. 460/1 (heading) Long-term potentiation of the parallel fiber-Purkinje cell synapse. 1989 B. Alberts et al. Molecular Biol. Cell (ed. 2) xix. 1100 The underlying rule in the hippocampus seems to be that long-term potentiation occurs on any occasion where a presynaptic cell fires (once or more) at a time when the postsynaptic membrane is strongly depolarized. 2001 Business Week 11 June 96/2 [The company] is developing drugs that will help the brain convert transient short-term memories into stable long-term ones. This process, called long-term potentiation, is compromised in the aging brain and in Alzheimer's victims. < as lemmas |
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