单词 | autoantigen |
释义 | > as lemmasautoantigen autoantigen n. Brit. /ˌɔːtəʊˈantᵻdʒ(ə)n/ , U.S. /ˌɔdoʊˈæn(t)ədʒ(ə)n/ , /ˌɔdoʊˈæn(t)əˌdʒɛn/ , /ˌɑdoʊˈæn(t)ədʒ(ə)n/ , /ˌɑdoʊˈæn(t)əˌdʒɛn/ Medicine and Immunology (a) an antigenic preparation made from a patient's own bacterial flora, secretions, or tissue (now disused); (b) an antigen that is the target of an autoimmune response.ΚΠ 1913 W. B. Christopherson tr. B. Bandelier & O. Roepke Tuberculin in Diagnosis & Treatm. iii. 195 Similar experiments to treat tuberculosis with a filtrate obtained from the patients' own sputum, which might be termed an auto-antigen, have lately been made. 1920 Amer. Jrnl. Dis. Children 19 411 Better results were obtained from the autoantigen. In the majority of cases benefit was immediately manifested. 1959 Internat. Arch. Allergy & Appl. Immunol. Suppl. 14 21 There was an organ-specific antigen..which could act as an auto-antigen. 2006 P. J. Delves et al. Roitt's Essent. Immunol. (ed. 11) 33/1 Hypersensitivity to autoantigens may arise through a breakdown in the mechanisms which control self tolerance. < as lemmas |
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