lepromatousadj.

Brit.

/lɛˈprəʊmətəs/, U.S.

/lɛˈproʊmədəs/

Origin: Formed within English, by derivation. Etymons: leproma n., -ous suffix.

Etymology: < lepromata, plural of leproma n. + -ous suffix.

Medicine.

1. Of, relating to, or of the nature of a leproma; containing a leproma or lepromas.

ΚΠ

1888 Ann. Universal Med. Sci. 2 381 But tears, nasal secretion and saliva swarm with bacilli in all cases where the ocular, nasal or bucco-pharyngeal surfaces are lepromatous.

1898 P. Manson Trop. Dis. xxvi. 397 The eyes also [in a leper] are sooner or later attacked, lepromatous growth spreading from the conjunctiva on to the cornea.

1915 O. S. Ormsby Pract. Treat. Dis. Skin 812 These organisms may be recognized in the tissues, in serum obtained from involved regions, in blood made to exude from lepromatous nodules, in nasal discharges, and in the secretions of ulcers.

1981 Jrnl. Bacteriol. 147 728 Surprisingly large quantities..of the glycolipid were also found in infected liver residue freed of M. leprae, suggesting that it may be responsible for the electron-transparent ‘foam’ surrounding the organism in lepromatous tissue.

2009 Vet. Ophthalmol. 12 97 (title) Isolated lepromatous conjunctivo-corneal granuloma in a cat from Italy.

2. Designating a severe form of leprosy with multiple lesions of the skin, nerves, mucous membranes, and other organs, occurring in persons who fail to develop a cell-mediated immune response to the causative agent of leprosy, Mycobacterium leprae. Also: of, relating to, or affected with this form of leprosy.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of visible parts > skin disorders > [adjective] > leprosy

leprous?1457

leproid1839

lepromatous1938

1938 Internat. Jrnl. Leprosy 6 390 Lepromatous (L) type.—All cases of the ‘malignant’ form of leprosy, relatively nonresistant and of poor prognosis, usually negative to leprolin, exhibiting lepromatous lesions of the skin and of other organs, especially the nerve trunks.

1962 Lancet 26 May 1116/2 If the altered tissue response could be maintained by repeated B.C.G. vaccination, this might prove a beneficial adjunct to chemotherapy in lepromatous leprosy.

1984 Arch. Pathol. & Lab. Med. 108 383 Biopsy specimens from 14 lepromatous patients..were compared with biopsy specimens from one borderline lepromatous and three borderline tuberculoid patients.

1991 A. Nikiforuk Fourth Horseman iii. 31 Defeat comes in the grotesque and infectious costume of lepromatous leprosy, which erodes noses..and contorts hands and feet into claws.

2010 Human Immunol. 71 992/1 Leprosy is characterized by a spectrum of clinical manifestations from tuberculoid to lepromatous poles that correlate with the type of cell-mediated immunity that the host develops against the bacillus.

This entry has been updated (OED Third Edition, December 2012; most recently modified version published online March 2022).

单词	lepromatous
释义	lepromatousadj. Brit. /lɛˈprəʊmətəs/, U.S. /lɛˈproʊmədəs/ Origin: Formed within English, by derivation. Etymons: leproma n., -ous suffix. Etymology: < lepromata, plural of leproma n. + -ous suffix. Medicine. 1. Of, relating to, or of the nature of a leproma; containing a leproma or lepromas. ΚΠ 1888 Ann. Universal Med. Sci. 2 381 But tears, nasal secretion and saliva swarm with bacilli in all cases where the ocular, nasal or bucco-pharyngeal surfaces are lepromatous. 1898 P. Manson Trop. Dis. xxvi. 397 The eyes also [in a leper] are sooner or later attacked, lepromatous growth spreading from the conjunctiva on to the cornea. 1915 O. S. Ormsby Pract. Treat. Dis. Skin 812 These organisms may be recognized in the tissues, in serum obtained from involved regions, in blood made to exude from lepromatous nodules, in nasal discharges, and in the secretions of ulcers. 1981 Jrnl. Bacteriol. 147 728 Surprisingly large quantities..of the glycolipid were also found in infected liver residue freed of M. leprae, suggesting that it may be responsible for the electron-transparent ‘foam’ surrounding the organism in lepromatous tissue. 2009 Vet. Ophthalmol. 12 97 (title) Isolated lepromatous conjunctivo-corneal granuloma in a cat from Italy. 2. Designating a severe form of leprosy with multiple lesions of the skin, nerves, mucous membranes, and other organs, occurring in persons who fail to develop a cell-mediated immune response to the causative agent of leprosy, Mycobacterium leprae. Also: of, relating to, or affected with this form of leprosy. ΘΚΠ the world > health and disease > ill health > a disease > disorders of visible parts > skin disorders > [adjective] > leprosy leprous?1457 leproid1839 lepromatous1938 1938 Internat. Jrnl. Leprosy 6 390 Lepromatous (L) type.—All cases of the ‘malignant’ form of leprosy, relatively nonresistant and of poor prognosis, usually negative to leprolin, exhibiting lepromatous lesions of the skin and of other organs, especially the nerve trunks. 1962 Lancet 26 May 1116/2 If the altered tissue response could be maintained by repeated B.C.G. vaccination, this might prove a beneficial adjunct to chemotherapy in lepromatous leprosy. 1984 Arch. Pathol. & Lab. Med. 108 383 Biopsy specimens from 14 lepromatous patients..were compared with biopsy specimens from one borderline lepromatous and three borderline tuberculoid patients. 1991 A. Nikiforuk Fourth Horseman iii. 31 Defeat comes in the grotesque and infectious costume of lepromatous leprosy, which erodes noses..and contorts hands and feet into claws. 2010 Human Immunol. 71 992/1 Leprosy is characterized by a spectrum of clinical manifestations from tuberculoid to lepromatous poles that correlate with the type of cell-mediated immunity that the host develops against the bacillus. This entry has been updated (OED Third Edition, December 2012; most recently modified version published online March 2022). < adj.1888
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