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leukodystrophy
leukodystrophy n. 
/ˌlukoʊˈdɪstrəfi/ [ < modern Latin leukodystrophia, coined in German (Bielschowsky and Hennenberg 1928, in Jrnl. f. Psychol. u. Neurol. 36 180)] Pathology any of several disorders of the white matter of the central nervous system (sometimes also affecting peripheral nerves), characterized by defective formation or breakdown of myelin; cf. leucoencephalitis n. at Additions.
Brit. /ˌl(j)uːkə(ʊ)ˈdɪstrəfi/
, /ˌl(j)uːkə(ʊ)ˈdɪstrəfi/U.S. /ˌlukəˈdɪstrəfi/
, /ˌlukəˈdɪstrəfi//ˌlukoʊˈdɪstrəfi/ΘΚΠ
the world > health and disease > ill health > a disease > disorders of internal organs > disorders of nervous system > [noun] > other nervous disorders
ciguatera1862
gangliopathy1868
hepato-lenticular degeneration1922
ganglionopathy1952
leukodystrophy1960
smon1971
Tourette('s) syndrome1973
1960 Jrnl. Neuropath. & Exper. Neurol. 19 334 A survey of the literature shows that there are apparently only 10 reported instances of pathologically verified cases of infantile metachromatic leukodystrophy.
1984 J. R. Tighe & D. R. Davies Pathol. (ed. 4) xxv. 245 The leucodystrophies are abnormalities of myelin leading to deficient myelination.
1991 Lancet 21 Dec. 1603/1 We report here on our experience with this drug in the symptomatic treatment of spasticity due to metabolic diseases with leukodystrophy in six children.
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