leucovorinn.

/l(j)uːˈkɒvərɪn/

Etymology: < modern Latin Leuco(nostoc ( < Greek λευκο- leuco- comb. form + nostoc n.), the generic name + citro)vor(um ( < citro- comb. form, + Latin vorāre to devour + -um ) the specific epithet, of the bacterium whose growth it was originally found to promote: see -in suffix¹.

Biochemistry.

= folinic acid n.

ΚΠ

1951 H. P. Broquist et al. in Federation Proc. (Federation Amer. Soc. Exper. Biol.) 10 167/1 A crystalline substance with the properties of the ‘citrovorum factor’ (CF) was prepared from pteroylglutamic acid... The amounts of this crystalline substance, ‘leucovorin’, required for half-maximum growth per ml. of PGA-deficient medium were 0·00015 μg. for Leuconostoc citrovorum 8081.

1954 Poultry Sci. XXXIII. 111/1 Leucovorin (synthetic citrovorum factor) appeared to be inferior to folacin in the nutrition of the chick.

1966 E. S. West et al. Textbk. Biochem. (ed. 4) xviii. 814 Folinic acid, citrovorum factor (CF), and leucovorin are names for a naturally occurring derivative of folic acid... It is N⁵-formyl-5,6,7,8-tetrahydropteroylglutamic acid.

1971 Cancer XXVIII. 899/1 The combination of methotrexate with Leucovorin rescue is a well-tolerated therapeutic maneuver.

This entry has not yet been fully updated (first published 1976; most recently modified version published online June 2021).

单词	leucovorin
释义	leucovorinn. /l(j)uːˈkɒvərɪn/ Etymology: < modern Latin Leuco(nostoc ( < Greek λευκο- leuco- comb. form + nostoc n.), the generic name + citro)vor(um ( < citro- comb. form, + Latin vorāre to devour + -um ) the specific epithet, of the bacterium whose growth it was originally found to promote: see -in suffix¹. Biochemistry. = folinic acid n. ΚΠ 1951 H. P. Broquist et al. in Federation Proc. (Federation Amer. Soc. Exper. Biol.) 10 167/1 A crystalline substance with the properties of the ‘citrovorum factor’ (CF) was prepared from pteroylglutamic acid... The amounts of this crystalline substance, ‘leucovorin’, required for half-maximum growth per ml. of PGA-deficient medium were 0·00015 μg. for Leuconostoc citrovorum 8081. 1954 Poultry Sci. XXXIII. 111/1 Leucovorin (synthetic citrovorum factor) appeared to be inferior to folacin in the nutrition of the chick. 1966 E. S. West et al. Textbk. Biochem. (ed. 4) xviii. 814 Folinic acid, citrovorum factor (CF), and leucovorin are names for a naturally occurring derivative of folic acid... It is N⁵-formyl-5,6,7,8-tetrahydropteroylglutamic acid. 1971 Cancer XXVIII. 899/1 The combination of methotrexate with Leucovorin rescue is a well-tolerated therapeutic maneuver. This entry has not yet been fully updated (first published 1976; most recently modified version published online June 2021). < n.1951
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