autophosphorylationn.
/ˌɔːtə(ʊ)ˌfɒsfɒrᵻˈleɪʃn/, U.S. /ˌɔdoʊfɑsˌfɔrəˈleɪʃ(ə)n/, /ˌɑdoʊfɑsˌfɔrəˈleɪʃ(ə)n/ Biochemistry.
Phosphorylation of a protein molecule which is catalysed by the kinase activity of the protein molecule itself.
ΚΠ
1972 FEBS Lett. 26 351/1 Fig. 3 shows the kinetics of autophosphorylation of brain (A) and thyroid (B) purified tubulin incubated with [γ-32P] ATP.
1989 J. Espinal Understanding Insulin Action v. 93 The autophosphorylation of the insulin receptor has been reported to occur in many tissues and cell types.
2006 Science 28 Apr. 572/3 In cells undergoing ER stress, BiP preferentially binds to misfolded proteins, thereby releasing the stress sensors to undergo activation by homodimerization and autophosphorylation.
This is a new entry (OED Third Edition, June 2011; most recently modified version published online December 2021).
<
n.1972