lactamasen.
/ˈlaktəmeɪz//ˈlaktəmeɪs/ Biochemistry.
β-lactamase: any of the enzymes (produced by certain bacteria) which cause the breaking of the carbon-nitrogen bond in the lactam ring of penicillins and cephalosporins (so rendering them ineffective as antibiotics).
ΚΠ
1964 Jrnl. Gen. Microbiol. 36 206 Amidase-forming coliform organisms did not attack the 6-APA nucleus, whereas β-lactamase-forming coliform organisms opened the lactam ring.
1971 N. Citri in P. D. Boyer et al. Enzymes (ed. 3) IV. ii. 24 The role of penicillinase and other β-lactamases in conferring resistance to penicillins and the closely related cephalosporins has been amply demonstrated.
This entry has not yet been fully updated (first published 1976; most recently modified version published online September 2018).
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