khellinn.

/ˈkɛlɪn/

Forms: Also † kellin.

Etymology: Originally coined as French kelline (I. Mustapha 1879, in Compt. Rend. LXXXIX. 442), < kell , given as the Arabic name of Ammi visnaga; the h originated with Samaan (1931), who gave the Arabic name as khella : see -in suffix¹.

A tricyclic crystalline compound, C₁₄H₁₂O₅, obtained from the fruit of the North African umbelliferous plant Ammi visnaga and formerly used in the treatment of angina pectoris. The name was originally given to the glucoside of this compound.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations for treating specific parts > [noun] > for the heart > specific drugs

khellin1879

procainamide1950

pronethalol1963

propranolol1964

alprenolol1967

verapamil1967

oxprenolol1968

sotalol1968

perhexiline1969

practolol1969

beta-blocker1970

pindolol1971

acebutolol1972

mexiletine1973

atenolol1974

metoprolol1974

labetalol1975

propafenone1975

amrinone1977

1879 Jrnl. Chem. Soc. 36 1041 The author proposes for this glucoside the name kellin, from the Arabic name of the Ammi Visnaga.

1931 K. Samaan in Q. Jrnl. Pharmacy & Pharmacol. 4 14 Ibrahim Mostapha described a crystalline principle which he named Khellin.

1938 Chem. Abstr. 32 2120 Fantl and Salem..obtained from the fruits of Ammi visnaga a compd., kellin, C₁₄H₁₂O₅.

1947 Lancet 26 Apr. 557/2 Khellin causes a conspicuous and long relaxation of all the visceral smooth muscle—the intestines, uterus, bile-ducts, bronchi, and especially ureters.

1947 Lancet 26 Apr. 557/2 In 1945 a fresh interest in khellin arose as the result of the discovery that it acts as an extremely potent coronary vasodilator which, in doses used, has no effect on the general blood-pressure and does not increase the oxygen requirements of the heart.

1957 M. Plotz Coronary Heart Dis. xvii. 301/2 Favorable results with khellin therapy in man have been reported by many investigators.

1957 M. Plotz Coronary Heart Dis. xvii. 301/2 The most important factor limiting the use of khellin orally has been the high incidence of toxic reactions.

1964 To-Day's Drugs (B.M.A.) 132 Khellin had a brief period of popularity about ten years ago, but when the drug was evaluated by controlled clinical trials and by objective methods it was found that it was no better than a placebo.

This entry has not yet been fully updated (first published 1976; most recently modified version published online June 2021).

单词	khellin
释义	khellinn. /ˈkɛlɪn/ Forms: Also † kellin. Etymology: Originally coined as French kelline (I. Mustapha 1879, in Compt. Rend. LXXXIX. 442), < kell , given as the Arabic name of Ammi visnaga; the h originated with Samaan (1931), who gave the Arabic name as khella : see -in suffix¹. A tricyclic crystalline compound, C₁₄H₁₂O₅, obtained from the fruit of the North African umbelliferous plant Ammi visnaga and formerly used in the treatment of angina pectoris. The name was originally given to the glucoside of this compound. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations for treating specific parts > [noun] > for the heart > specific drugs khellin1879 procainamide1950 pronethalol1963 propranolol1964 alprenolol1967 verapamil1967 oxprenolol1968 sotalol1968 perhexiline1969 practolol1969 beta-blocker1970 pindolol1971 acebutolol1972 mexiletine1973 atenolol1974 metoprolol1974 labetalol1975 propafenone1975 amrinone1977 1879 Jrnl. Chem. Soc. 36 1041 The author proposes for this glucoside the name kellin, from the Arabic name of the Ammi Visnaga. 1931 K. Samaan in Q. Jrnl. Pharmacy & Pharmacol. 4 14 Ibrahim Mostapha described a crystalline principle which he named Khellin. 1938 Chem. Abstr. 32 2120 Fantl and Salem..obtained from the fruits of Ammi visnaga a compd., kellin, C₁₄H₁₂O₅. 1947 Lancet 26 Apr. 557/2 Khellin causes a conspicuous and long relaxation of all the visceral smooth muscle—the intestines, uterus, bile-ducts, bronchi, and especially ureters. 1947 Lancet 26 Apr. 557/2 In 1945 a fresh interest in khellin arose as the result of the discovery that it acts as an extremely potent coronary vasodilator which, in doses used, has no effect on the general blood-pressure and does not increase the oxygen requirements of the heart. 1957 M. Plotz Coronary Heart Dis. xvii. 301/2 Favorable results with khellin therapy in man have been reported by many investigators. 1957 M. Plotz Coronary Heart Dis. xvii. 301/2 The most important factor limiting the use of khellin orally has been the high incidence of toxic reactions. 1964 To-Day's Drugs (B.M.A.) 132 Khellin had a brief period of popularity about ten years ago, but when the drug was evaluated by controlled clinical trials and by objective methods it was found that it was no better than a placebo. This entry has not yet been fully updated (first published 1976; most recently modified version published online June 2021). < n.1879
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